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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2247
Target Type SINGLE PROTEIN
Preferred Name Atrial natriuretic peptide receptor C
Synonyms ANP-C | ANPR-C | ANPRC | Atrial natriuretic peptide clearance receptor | Atrial natriuretic peptide receptor 3 | Atrial natriuretic peptide receptor type C | C5orf23 | NPR-C | NPR3 | NPRC
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Atrial natriuretic peptide receptor 3 SINGLE PROTEIN P17342

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111337 Atrial natriuretic peptide receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000113389
Ensembl ENSG00000113389
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004016 (adenylate cyclase activity)
GO:0008528 (G-protein coupled peptide receptor activity)
GO:0016941 (natriuretic peptide receptor activity)
GO:0017046 (peptide hormone binding)
GO:0042562 (hormone binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0001501 (skeletal system development)
GO:0002158 (osteoclast proliferation)
GO:0006171 (cAMP biosynthetic process)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0008217 (regulation of blood pressure)
GO:0009190 (cyclic nucleotide biosynthetic process)
GO:0019933 (cAMP-mediated signaling)
GO:0030157 (pancreatic juice secretion)
GO:0033688 (regulation of osteoblast proliferation)
GO:0035810 (positive regulation of urine volume)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0048662 (negative regulation of smooth muscle cell proliferation)
GO:0051000 (positive regulation of nitric-oxide synthase activity)

Target Cross References - Protein

canSAR P17342
Human Protein Atlas ENSG00000113389
Guide to Pharmacology 1749
Open Targets ENSG00000113389
PharmGKB PA31737
UniProt A2RRD1 B4DT84 E7EPG9 P17342

Target Cross References - Domain

InterPro IPR001170 (ANPR/GUC.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR028082 (Peripla_BP_I.)
Pfam PF01094 (ANF_receptor)

Target Cross References - Structure

PDBe 1JDN 1JDP 1YK0 1YK1
CREDO 1JDN 1JDP 1YK0 1YK1
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