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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2243
Preferred Name Anandamide amidohydrolase
Synonyms Anandamide amidohydrolase 1 | FAAH | FAAH1 | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Fatty-acid amide hydrolase 1 SINGLE PROTEIN O00519

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL112 ACETAMINOPHEN Anandamide amidohydrolase inhibitor 4 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117480
Ensembl ENSG00000117480
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005856 (cytoskeleton)
GO:0012505 (endomembrane system)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031090 (organelle membrane)
GO Molecular Function GO:0004040 (amidase activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0017064 (fatty acid amide hydrolase activity)
GO:0047372 (acylglycerol lipase activity)
GO:0102077 (oleamide hydrolase activity)
GO:0103073 (anandamide amidohydrolase activity)
GO Biological Process GO:0009062 (fatty acid catabolic process)
GO:0019369 (arachidonic acid metabolic process)

Target Cross References - Protein

canSAR O00519
Human Protein Atlas ENSG00000117480
IntAct O00519
Guide to Pharmacology 1400
Open Targets ENSG00000117480
PharmGKB PA27955
Reactome R-HSA-2142753 (Arachidonic acid metabolism.)
UniProt D3DQ19 O00519 Q52M86 Q5TDF8

Target Cross References - Domain

InterPro IPR000120 (Amidase.)
IPR020556 (Amidase_CS.)
IPR023631 (Amidase_dom.)
IPR030560 (FAAH.)
IPR036928 (AS_sf.)
Pfam PF01425 (Amidase)