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Target Report Card

Target Name and Classification

Target ID CHEMBL2237
Preferred Name Adenosine A2b receptor
Synonyms Adenosine receptor A2b | Adora2b
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > nucleotide-like receptor (family a gpcr) > adenosine receptor

Target Components

Component Description Relationship Accession
Adenosine receptor A2b SINGLE PROTEIN Q60614

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0001609 (G-protein coupled adenosine receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO Biological Process GO:0001973 (adenosine receptor signaling pathway)
GO:0002882 (positive regulation of chronic inflammatory response to non-antigenic stimulus)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0010701 (positive regulation of norepinephrine secretion)
GO:0010893 (positive regulation of steroid biosynthetic process)
GO:0030828 (positive regulation of cGMP biosynthetic process)
GO:0031284 (positive regulation of guanylate cyclase activity)
GO:0031668 (cellular response to extracellular stimulus)
GO:0032722 (positive regulation of chemokine production)
GO:0032755 (positive regulation of interleukin-6 production)
GO:0032966 (negative regulation of collagen biosynthetic process)
GO:0033605 (positive regulation of catecholamine secretion)
GO:0043306 (positive regulation of mast cell degranulation)
GO:0043950 (positive regulation of cAMP-mediated signaling)
GO:0045765 (regulation of angiogenesis)
GO:0060087 (relaxation of vascular smooth muscle)
GO:0097755 (positive regulation of blood vessel diameter)

Target Cross References - Protein

Guide to Pharmacology 20
Reactome R-MMU-417973 (Adenosine P1 receptors.)
R-MMU-418555 (G alpha (s) signalling events.)
R-MMU-5683826 (Surfactant metabolism.)
UniProt Q60614 Q8BXI2

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001435 (Adeno_A2B_rcpt.)
IPR001634 (Adenosn_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)