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Target Report Card

Target Name and Classification

Target ID CHEMBL2231
Preferred Name Cytochrome P450 1A1
Synonyms CYP1A1 | CYPIA1 | Cytochrome P450 1A1 | Cytochrome P450 form 6 | Cytochrome P450-C | Cytochrome P450-P1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 1 > cytochrome p450 family 1a > cytochrome p450 1a1

Target Components

Component Description Relationship Accession
Cytochrome P450 1A1 SINGLE PROTEIN P04798

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3544905 Cytochrome P450 1A PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000140465
Ensembl ENSG00000140465
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0005515 (protein binding)
GO:0008395 (steroid hydroxylase activity)
GO:0016491 (oxidoreductase activity)
GO:0016679 (oxidoreductase activity, acting on diphenols and related substances as donors)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016711 (flavonoid 3'-monooxygenase activity)
GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
GO:0019825 (oxygen binding)
GO:0019899 (enzyme binding)
GO:0020037 (heme binding)
GO:0032451 (demethylase activity)
GO:0046872 (metal ion binding)
GO:0070330 (aromatase activity)
GO:0070576 (vitamin D 24-hydroxylase activity)
GO:0101020 (estrogen 16-alpha-hydroxylase activity)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0001889 (liver development)
GO:0002933 (lipid hydroxylation)
GO:0006778 (porphyrin-containing compound metabolic process)
GO:0007568 (aging)
GO:0008202 (steroid metabolic process)
GO:0008283 (cell proliferation)
GO:0009308 (amine metabolic process)
GO:0009404 (toxin metabolic process)
GO:0009611 (response to wounding)
GO:0009615 (response to virus)
GO:0009624 (response to nematode)
GO:0009635 (response to herbicide)
GO:0009636 (response to toxic substance)
GO:0009692 (ethylene metabolic process)
GO:0009804 (coumarin metabolic process)
GO:0009812 (flavonoid metabolic process)
GO:0010033 (response to organic substance)
GO:0010041 (response to iron(III) ion)
GO:0014070 (response to organic cyclic compound)
GO:0017143 (insecticide metabolic process)
GO:0017144 (drug metabolic process)
GO:0018894 (dibenzo-p-dioxin metabolic process)
GO:0019216 (regulation of lipid metabolic process)
GO:0019341 (dibenzo-p-dioxin catabolic process)
GO:0019373 (epoxygenase P450 pathway)
GO:0032094 (response to food)
GO:0032496 (response to lipopolysaccharide)
GO:0032502 (developmental process)
GO:0033189 (response to vitamin A)
GO:0035902 (response to immobilization stress)
GO:0042359 (vitamin D metabolic process)
GO:0042493 (response to drug)
GO:0042904 (9-cis-retinoic acid biosynthetic process)
GO:0043010 (camera-type eye development)
GO:0046483 (heterocycle metabolic process)
GO:0046677 (response to antibiotic)
GO:0046685 (response to arsenic-containing substance)
GO:0048565 (digestive tract development)
GO:0050665 (hydrogen peroxide biosynthetic process)
GO:0055093 (response to hyperoxia)
GO:0055114 (oxidation-reduction process)
GO:0060137 (maternal process involved in parturition)
GO:0070365 (hepatocyte differentiation)
GO:0070988 (demethylation)
GO:0071280 (cellular response to copper ion)
GO:0071407 (cellular response to organic cyclic compound)
GO:0097267 (omega-hydroxylase P450 pathway)
GO:1900087 (positive regulation of G1/S transition of mitotic cell cycle)
Wikipedia Cytochrome_P450,_family_1,_member_A1

Target Cross References - Protein

canSAR P04798
Human Protein Atlas ENSG00000140465
IntAct P04798
Guide to Pharmacology 1318
Open Targets ENSG00000140465
PharmGKB PA27092
Reactome R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-211981 (Xenobiotics.)
R-HSA-2142670 (Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).)
R-HSA-2142816 (Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).)
UniProt A4F3V9 A4F3W0 P04798 Q53G18

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR008066 (Cyt_P450_E_grp-I_CYP1.)
IPR017972 (Cyt_P450_CS.)
IPR036396 (Cyt_P450_sf.)
Pfam PF00067 (p450)

Target Cross References - Structure