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Target Report Card

Target Name and Classification

Target ID CHEMBL2216744
Preferred Name Vacuolar protein sorting-associated protein 35
Synonyms MEM3 | Maternal-embryonic 3 | VPS35 | Vacuolar protein sorting-associated protein 35 | Vesicle protein sorting 35 | hVPS35
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Vacuolar protein sorting-associated protein 35 SINGLE PROTEIN Q96QK1

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000069329
Ensembl ENSG00000069329
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005765 (lysosomal membrane)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005770 (late endosome)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0030904 (retromer complex)
GO:0030906 (retromer, cargo-selective complex)
GO:0070062 (extracellular exosome)
GO:0097422 (tubular endosome)
GO Molecular Function GO:0005515 (protein binding)
GO:0008565 (protein transporter activity)
GO Biological Process GO:0006810 (transport)
GO:0006886 (intracellular protein transport)
GO:0015031 (protein transport)
GO:0016055 (Wnt signaling pathway)
GO:0016241 (regulation of macroautophagy)
GO:0031647 (regulation of protein stability)
GO:0042147 (retrograde transport, endosome to Golgi)
GO:0045056 (transcytosis)
GO:0061357 (positive regulation of Wnt protein secretion)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
GO:1902823 (negative regulation of late endosome to lysosome transport)
GO:1990126 (retrograde transport, endosome to plasma membrane)

Target Cross References - Protein

CGD Parkinson disease 17
Human Protein Atlas ENSG00000069329
IntAct Q96QK1
Open Targets ENSG00000069329
PharmGKB PA37783
Reactome R-HSA-3238698 (WNT ligand biogenesis and trafficking.)
UniProt Q561W2 Q96QK1 Q9H016 Q9H096 Q9H4P3 Q9H8J0 Q9NRS7 Q9NVG2 Q9NX80 Q9NZK2

Target Cross References - Domain

InterPro IPR005378 (Vps35.)
IPR016024 (ARM-type_fold.)
Pfam PF03635 (Vps35)

Target Cross References - Structure

PDBe 2R17 5F0J 5F0K 5F0L 5F0M 5F0P
CREDO 2R17 5F0J 5F0K 5F0L 5F0M 5F0P