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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2213
Target Type SINGLE PROTEIN
Preferred Name Protein kinase C alpha
Synonyms PKC-A | PKC-alpha | PRKCA | Protein kinase C alpha type
Organism Bos taurus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pkc family > agc protein kinase pkc alpha subfamily

Target Components

Component Description Relationship Accession
Protein kinase C alpha type SINGLE PROTEIN P04409

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0031966 (mitochondrial membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO:0097381 (photoreceptor disc membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004697 (protein kinase C activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008270 (zinc ion binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007155 (cell adhesion)
GO:0010595 (positive regulation of endothelial cell migration)
GO:0010613 (positive regulation of cardiac muscle hypertrophy)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0030335 (positive regulation of cell migration)
GO:0031666 (positive regulation of lipopolysaccharide-mediated signaling pathway)
GO:0034351 (negative regulation of glial cell apoptotic process)
GO:0035556 (intracellular signal transduction)
GO:0045651 (positive regulation of macrophage differentiation)
GO:0045766 (positive regulation of angiogenesis)
GO:0045785 (positive regulation of cell adhesion)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0090330 (regulation of platelet aggregation)
GO:0106071 (positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:2000707 (positive regulation of dense core granule biogenesis)

Target Cross References - Protein

canSAR P04409
UniProt P04409

Target Cross References - Domain

InterPro IPR000008 (C2_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR002219 (PE/DAG-bd.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR014375 (Protein_kinase_C_a/b/g.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
IPR020454 (DAG/PE-bd.)
IPR034663 (cPKC_alpha.)
IPR035892 (C2_domain_sf.)
Pfam PF00069 (Pkinase)
PF00130 (C1_1)
PF00168 (C2)
PF00433 (Pkinase_C)
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