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Target Report Card

Target Name and Classification

Target ID CHEMBL2211
Preferred Name Serine/threonine-protein kinase Aurora-A
Synonyms ARK-1 | Aik | Airk | Ark1 | Aura | Aurka | Aurora 2 | Aurora family kinase 1 | Aurora kinase A | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | Ayk1 | Btak | Iak1 | Ipl1- and aurora-related kinase 1 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase Ayk1 | Serine/threonine-protein kinase aurora-A | Stk15 | Stk6
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase aur family

Target Components

Component Description Relationship Accession
Aurora kinase A SINGLE PROTEIN P97477

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0000780 (condensed nuclear chromosome, centromeric region)
GO:0000922 (spindle pole)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005814 (centriole)
GO:0005815 (microtubule organizing center)
GO:0005819 (spindle)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005874 (microtubule)
GO:0005876 (spindle microtubule)
GO:0005929 (cilium)
GO:0015630 (microtubule cytoskeleton)
GO:0031616 (spindle pole centrosome)
GO:0032133 (chromosome passenger complex)
GO:0042585 (germinal vesicle)
GO:0042995 (cell projection)
GO:0043203 (axon hillock)
GO:0045120 (pronucleus)
GO:0048471 (perinuclear region of cytoplasm)
GO:0051233 (spindle midzone)
GO:0072686 (mitotic spindle)
GO:0072687 (meiotic spindle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0035174 (histone serine kinase activity)
GO Biological Process GO:0000212 (meiotic spindle organization)
GO:0000226 (microtubule cytoskeleton organization)
GO:0000278 (mitotic cell cycle)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007051 (spindle organization)
GO:0007052 (mitotic spindle organization)
GO:0007057 (spindle assembly involved in female meiosis I)
GO:0007067 (mitotic nuclear division)
GO:0007100 (mitotic centrosome separation)
GO:0007126 (meiotic nuclear division)
GO:0009948 (anterior/posterior axis specification)
GO:0016310 (phosphorylation)
GO:0016925 (protein sumoylation)
GO:0030030 (cell projection organization)
GO:0031647 (regulation of protein stability)
GO:0032091 (negative regulation of protein binding)
GO:0032355 (response to estradiol)
GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0032465 (regulation of cytokinesis)
GO:0035404 (histone-serine phosphorylation)
GO:0043066 (negative regulation of apoptotic process)
GO:0051297 (centrosome organization)
GO:0051301 (cell division)
GO:0051321 (meiotic cell cycle)
GO:0051642 (centrosome localization)
GO:0071539 (protein localization to centrosome)
GO:1900195 (positive regulation of oocyte maturation)
GO:1990138 (neuron projection extension)

Target Cross References - Protein

canSAR P97477
IntAct P97477
Reactome R-MMU-174178 (APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.)
R-MMU-2565942 (Regulation of PLK1 Activity at G2/M Transition.)
R-MMU-4615885 (SUMOylation of DNA replication proteins.)
R-MMU-6804114 (TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.)
R-MMU-6804756 (Regulation of TP53 Activity through Phosphorylation.)
R-MMU-8854050 (FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.)
R-MMU-8854518 (AURKA Activation by TPX2.)
R-MMU-8854521 (Interaction between PHLDA1 and AURKA.)
UniProt O35624 P97477 Q8C3H8 Q91YU4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR030616 (Aur.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 3D14 3D15 3D2I 3D2K 3DAJ 3DJ5 3DJ6 3DJ7
CREDO 3D14 3D15 3D2I 3D2K 3DAJ 3DJ5 3DJ6 3DJ7