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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2189127
Target Type SINGLE PROTEIN
Preferred Name Monoacylglycerol lipase ABHD6
Synonyms 2-arachidonoylglycerol hydrolase | ABHD6 | Abhydrolase domain-containing protein 6 | Monoacylglycerol lipase ABHD6
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Monoacylglycerol lipase ABHD6 SINGLE PROTEIN Q9BV23

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000163686
Ensembl ENSG00000163686
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0032281 (AMPA glutamate receptor complex)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004620 (phospholipase activity)
GO:0016787 (hydrolase activity)
GO:0047372 (acylglycerol lipase activity)
GO Biological Process GO:0009395 (phospholipid catabolic process)
GO:0030336 (negative regulation of cell migration)
GO:0046464 (acylglycerol catabolic process)
GO:0046889 (positive regulation of lipid biosynthetic process)
GO:0060292 (long term synaptic depression)
GO:2000124 (regulation of endocannabinoid signaling pathway)

Target Cross References - Protein

Human Protein Atlas ENSG00000163686
IntAct Q9BV23
Open Targets ENSG00000163686
PharmGKB PA134916787
Reactome R-HSA-426048 (Arachidonate production from DAG.)
UniProt B2R7Y9 Q6ZMF7 Q9BV23

Target Cross References - Domain

InterPro IPR000073 (AB_hydrolase_1.)
IPR000639 (Epox_hydrolase-like.)
IPR029058 (AB_hydrolase.)
Pfam PF00561 (Abhydrolase_1)
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