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Target Report Card

Target Name and Classification

Target ID CHEMBL2179
Target Type SINGLE PROTEIN
Preferred Name Beta-glucocerebrosidase
Synonyms Acid beta-glucosidase | Alglucerase | Beta-GC | Beta-glucocerebrosidase | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GC | GLUC | Glucosylceramidase | Imiglucerase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Glucosylceramidase SINGLE PROTEIN P04062

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2105671 AFEGOSTAT TARTRATE Beta-glucocerebrosidase stabiliser 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000177628
Ensembl ENSG00000177628
GO Cellular Component GO:0005615 (extracellular space)
GO:0005764 (lysosome)
GO:0005765 (lysosomal membrane)
GO:0016020 (membrane)
GO:0019898 (extrinsic component of membrane)
GO:0043202 (lysosomal lumen)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004348 (glucosylceramidase activity)
GO:0005102 (receptor binding)
GO:0005124 (scavenger receptor binding)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0016798 (hydrolase activity, acting on glycosyl bonds)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006665 (sphingolipid metabolic process)
GO:0006680 (glucosylceramide catabolic process)
GO:0006687 (glycosphingolipid metabolic process)
GO:0007005 (mitochondrion organization)
GO:0008152 (metabolic process)
GO:0009267 (cellular response to starvation)
GO:0009268 (response to pH)
GO:0016241 (regulation of macroautophagy)
GO:0023021 (termination of signal transduction)
GO:0031175 (neuron projection development)
GO:0032268 (regulation of cellular protein metabolic process)
GO:0032269 (negative regulation of cellular protein metabolic process)
GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0032463 (negative regulation of protein homooligomerization)
GO:0032715 (negative regulation of interleukin-6 production)
GO:0033561 (regulation of water loss via skin)
GO:0033574 (response to testosterone)
GO:0035307 (positive regulation of protein dephosphorylation)
GO:0036473 (cell death in response to oxidative stress)
GO:0043243 (positive regulation of protein complex disassembly)
GO:0043407 (negative regulation of MAP kinase activity)
GO:0043589 (skin morphogenesis)
GO:0043627 (response to estrogen)
GO:0046512 (sphingosine biosynthetic process)
GO:0046513 (ceramide biosynthetic process)
GO:0050728 (negative regulation of inflammatory response)
GO:0051246 (regulation of protein metabolic process)
GO:0051247 (positive regulation of protein metabolic process)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0071548 (response to dexamethasone)
GO:0097066 (response to thyroid hormone)
GO:1901215 (negative regulation of neuron death)
GO:1901805 (beta-glucoside catabolic process)
GO:1903052 (positive regulation of proteolysis involved in cellular protein catabolic process)
GO:1903061 (positive regulation of protein lipidation)
GO:1904457 (positive regulation of neuronal action potential)
GO:1904925 (positive regulation of mitophagy in response to mitochondrial depolarization)
GO:1905037 (autophagosome organization)
GO:1905165 (regulation of lysosomal protein catabolic process)
Wikipedia Glucocerebrosidase

Target Cross References - Protein

canSAR P04062
CGD Gaucher disease
Human Protein Atlas ENSG00000177628
IntAct P04062
Open Targets ENSG00000177628
PharmGKB PA28591
Reactome R-HSA-1660662 (Glycosphingolipid metabolism.)
R-HSA-390471 (Association of TriC/CCT with target proteins during biosynthesis.)
UniProt A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 P04062 Q16545 Q4VX22 Q6I9R6 Q9UMJ8

Target Cross References - Domain

InterPro IPR001139 (Glyco_hydro_30.)
IPR013780 (Glyco_hydro_b.)
IPR017853 (Glycoside_hydrolase_SF.)
IPR033452 (GH30_C.)
IPR033453 (Glyco_hydro_30_TIM-barrel.)
Pfam PF02055 (Glyco_hydro_30)
PF17189 (Glyco_hydro_30C)

Target Cross References - Structure

PDBe 1OGS 1Y7V 2F61 2J25 2NSX 2NT0 2NT1 2V3D 2V3E 2V3F 2VT0 2WCG 2WKL 2XWD 2XWE 3GXD 3GXF 3GXI 3GXM 3KE0 3KEH 3RIK 3RIL 5LVX
CREDO 1OGS 1Y7V 2F61 2J25 2NSX 2NT0 2NT1 2V3D 2V3E 2V3F 2VT0 2WCG 2WKL 2XWD 2XWE 3GXD 3GXF 3GXI 3GXM 3KE0 3KEH 3RIK 3RIL 5LVX
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