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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2176773
Target Type SINGLE PROTEIN
Preferred Name PH-interacting protein
Synonyms IRS-1 PH domain-binding protein | PH-interacting protein | PHIP | PHIP | WD repeat-containing protein 11 | WDR11
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > reader > bromodomain

Target Components

Component Description Relationship Accession
PH-interacting protein SINGLE PROTEIN Q8WWQ0

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000146247
Ensembl ENSG00000146247
GO Cellular Component GO:0005634 (nucleus)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005158 (insulin receptor binding)
GO:0005515 (protein binding)
GO:0070577 (lysine-acetylated histone binding)
GO Biological Process GO:0001932 (regulation of protein phosphorylation)
GO:0007010 (cytoskeleton organization)
GO:0008284 (positive regulation of cell proliferation)
GO:0008286 (insulin receptor signaling pathway)
GO:0008360 (regulation of cell shape)
GO:0022604 (regulation of cell morphogenesis)
GO:0043066 (negative regulation of apoptotic process)
GO:0043568 (positive regulation of insulin-like growth factor receptor signaling pathway)
GO:0045840 (positive regulation of mitotic nuclear division)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway)

Target Cross References - Protein

Human Protein Atlas ENSG00000146247
IntAct Q8WWQ0
Open Targets ENSG00000146247
PharmGKB PA33265
UniProt A7J992 B2RPK4 Q05CQ9 Q5VVH4 Q66I29 Q69YV1 Q8NBZ5 Q8WWQ0 Q96H52 Q96ME2 Q9H261

Target Cross References - Domain

InterPro IPR001487 (Bromodomain.)
IPR001680 (WD40_repeat.)
IPR015943 (WD40/YVTN_repeat-like_dom.)
IPR017986 (WD40_repeat_dom.)
IPR018359 (Bromodomain_CS.)
IPR019775 (WD40_repeat_CS.)
IPR028738 (PHIP.)
Pfam PF00400 (WD40)
PF00439 (Bromodomain)

Target Cross References - Structure

PDBe 3MB3 5ENB 5ENC 5ENE 5ENF 5ENH 5ENI 5ENJ
CREDO 3MB3 5ENB 5ENC 5ENE 5ENF 5ENH 5ENI 5ENJ
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