ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL216
Target Type SINGLE PROTEIN
Preferred Name Muscarinic acetylcholine receptor M1
Synonyms CHRM1 | Muscarinic acetylcholine receptor M1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > acetylcholine receptor

Target Components

Component Description Relationship Accession
Muscarinic acetylcholine receptor M1 SINGLE PROTEIN P11229

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094109 Muscarinic acetylcholine receptor PROTEIN FAMILY
CHEMBL2095219 Muscarinic acetylcholine receptors; M1 & M2 SELECTIVITY GROUP
CHEMBL2111417 Muscarinic acetylcholine receptor M1/M5 chimeric protein CHIMERIC PROTEIN
CHEMBL2111418 Muscarinic acetylcholine receptor M1 and M3 SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL550 PILOCARPINE Muscarinic acetylcholine receptor M1 agonist 4 PubMed
CHEMBL1092 TRIHEXYPHENIDYL HYDROCHLORIDE Muscarinic acetylcholine receptor M1 antagonist 4 ISBN PubMed PubMed
CHEMBL1240 PROPANTHELINE BROMIDE Muscarinic acetylcholine receptor M1 antagonist 4 ISBN PubMed PubMed PubMed PubMed PubMed
CHEMBL1529 DIPHENIDOL HYDROCHLORIDE Muscarinic acetylcholine receptor M1 antagonist 4 ISBN PubMed PubMed PubMed
CHEMBL517712 ATROPINE Muscarinic acetylcholine receptor M1 antagonist 4 FDA ISBN
CHEMBL1578 ANISOTROPINE METHYLBROMIDE Muscarinic acetylcholine receptor M1 antagonist 4 PubMed PubMed
CHEMBL1724 MEPENZOLATE BROMIDE Muscarinic acetylcholine receptor M1 antagonist 4 ISBN PubMed PubMed
CHEMBL1761 PROCYCLIDINE HYDROCHLORIDE Muscarinic acetylcholine receptor M1 antagonist 4 ISBN PubMed
CHEMBL1187846 SCOPOLAMINE Muscarinic acetylcholine receptor M1 antagonist 4 ISBN PubMed
CHEMBL1200330 PILOCARPINE HYDROCHLORIDE Muscarinic acetylcholine receptor M1 agonist 4 PubMed
CHEMBL1200347 ISOPROPAMIDE IODIDE Muscarinic acetylcholine receptor M1 antagonist 4 ISBN PubMed PubMed
CHEMBL1200383 BENZTROPINE MESYLATE Muscarinic acetylcholine receptor M1 antagonist 4 DailyMed FDA ISBN
CHEMBL1200426 METHIXENE HYDROCHLORIDE Muscarinic acetylcholine receptor M1 antagonist 4 ISBN PubMed
CHEMBL1200479 DICYCLOMINE HYDROCHLORIDE Muscarinic acetylcholine receptor M1 antagonist 4 DailyMed ISBN
CHEMBL1200771 TRIDIHEXETHYL CHLORIDE Muscarinic acetylcholine receptor M1 antagonist 4 ISBN PubMed
CHEMBL1200828 CYCRIMINE HYDROCHLORIDE Muscarinic acetylcholine receptor M1 antagonist 4 ISBN PubMed PubMed
CHEMBL1200880 DIPHEMANIL METHYLSULFATE Muscarinic acetylcholine receptor M1 antagonist 4 ISBN PubMed
CHEMBL1200891 OXYPHENCYCLIMINE HYDROCHLORIDE Muscarinic acetylcholine receptor M1 antagonist 4 ISBN PubMed PubMed
CHEMBL1200906 OXYPHENONIUM BROMIDE Muscarinic acetylcholine receptor M1 antagonist 4 ISBN PubMed
CHEMBL1200950 CLIDINIUM BROMIDE Muscarinic acetylcholine receptor M1 antagonist 4 DailyMed DailyMed ISBN
CHEMBL1200970 ETHOPROPAZINE HYDROCHLORIDE Muscarinic acetylcholine receptor M1 antagonist 4 ISBN PubMed
CHEMBL1201024 METHSCOPOLAMINE BROMIDE Muscarinic acetylcholine receptor M1 antagonist 4 DailyMed ISBN
CHEMBL1201027 GLYCOPYRROLATE BROMIDE Muscarinic acetylcholine receptor M1 antagonist 4 DailyMed ISBN PubMed
CHEMBL1201035 BIPERIDEN HYDROCHLORIDE Muscarinic acetylcholine receptor M1 antagonist 4 DailyMed ISBN
CHEMBL1201067 BIPERIDEN LACTATE Muscarinic acetylcholine receptor M1 antagonist 4 DailyMed ISBN
CHEMBL1626570 HEXOCYCLIUM METHYLSULFATE Muscarinic acetylcholine receptor M1 antagonist 4 ISBN PubMed PubMed
CHEMBL2146146 ATROPINE SULFATE Muscarinic acetylcholine receptor M1 antagonist 4 FDA ISBN
CHEMBL2218917 CEVIMELINE HYDROCHLORIDE Muscarinic acetylcholine receptor M1 agonist 4 DailyMed ISBN PubMed
CHEMBL3707249 ASM-024 Muscarinic acetylcholine receptor M1 antagonist 2 PubMed PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000168539
Ensembl ENSG00000168539
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0032279 (asymmetric synapse)
GO:0043679 (axon terminus)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004435 (phosphatidylinositol phospholipase C activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0008144 (drug binding)
GO:0016907 (G-protein coupled acetylcholine receptor activity)
GO Biological Process GO:0003056 (regulation of vascular smooth muscle contraction)
GO:0006464 (cellular protein modification process)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007197 (adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway)
GO:0007205 (protein kinase C-activating G-protein coupled receptor signaling pathway)
GO:0007207 (phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway)
GO:0007213 (G-protein coupled acetylcholine receptor signaling pathway)
GO:0007271 (synaptic transmission, cholinergic)
GO:0007274 (neuromuscular synaptic transmission)
GO:0007399 (nervous system development)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
GO:0040012 (regulation of locomotion)
GO:0043270 (positive regulation of ion transport)
GO:0046541 (saliva secretion)
GO:0050890 (cognition)
GO:0090316 (positive regulation of intracellular protein transport)
Wikipedia Muscarinic_acetylcholine_receptor_M1

Target Cross References - Protein

canSAR P11229
Human Protein Atlas ENSG00000168539
IntAct P11229
Guide to Pharmacology 13
Open Targets ENSG00000168539
PharmGKB PA26484
Pharos P11229 (Tclin)
Reactome R-HSA-390648 (Muscarinic acetylcholine receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
UniProt P11229 Q96RH1

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000995 (Musac_Ach_rcpt.)
IPR002228 (Musac_Ach_M1_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 5CXV
CREDO 5CXV
spacer
spacer