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Target Report Card

Target Name and Classification

Target ID CHEMBL215
Preferred Name Arachidonate 5-lipoxygenase
Synonyms 5-LO | 5-lipoxygenase | ALOX5 | Arachidonate 5-lipoxygenase | LOG5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Arachidonate 5-lipoxygenase SINGLE PROTEIN P09917

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111402 5-lipoxygenase/FLAP PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL421 SULFASALAZINE Arachidonate 5-lipoxygenase inhibitor 4 PubMed PubMed PubMed
CHEMBL93 ZILEUTON Arachidonate 5-lipoxygenase inhibitor 4 DailyMed
CHEMBL704 MESALAMINE Arachidonate 5-lipoxygenase inhibitor 4 PubMed PubMed PubMed
CHEMBL1200760 BALSALAZIDE DISODIUM Arachidonate 5-lipoxygenase inhibitor 4 PubMed PubMed
CHEMBL1201013 OLSALAZINE SODIUM Arachidonate 5-lipoxygenase inhibitor 4 DailyMed PubMed PubMed PubMed
CHEMBL1562610 MECLOFENAMATE SODIUM Arachidonate 5-lipoxygenase inhibitor 4 DailyMed PubMed
CHEMBL59356 ATRELEUTON Arachidonate 5-lipoxygenase inhibitor 2 PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000012779 ENSG00000275565
Ensembl ENSG00000012779 ENSG00000275565
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005641 (nuclear envelope lumen)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0016363 (nuclear matrix)
GO:0031965 (nuclear membrane)
GO:0034774 (secretory granule lumen)
GO:1904813 (ficolin-1-rich granule lumen)
GO Molecular Function GO:0004051 (arachidonate 5-lipoxygenase activity)
GO:0005506 (iron ion binding)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0016702 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)
GO:0046872 (metal ion binding)
GO:0051213 (dioxygenase activity)
GO Biological Process GO:0002540 (leukotriene production involved in inflammatory response)
GO:0006691 (leukotriene metabolic process)
GO:0006954 (inflammatory response)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0019370 (leukotriene biosynthetic process)
GO:0019372 (lipoxygenase pathway)
GO:0035655 (interleukin-18-mediated signaling pathway)
GO:0043312 (neutrophil degranulation)
GO:0055114 (oxidation-reduction process)
GO:2001301 (lipoxin biosynthetic process)
Wikipedia Arachidonate_5-lipoxygenase

Target Cross References - Protein

canSAR P09917
CGD Asthma, diminished response to antileukotriene treatment in
Human Protein Atlas ENSG00000012779 ENSG00000275565
IntAct P09917
Guide to Pharmacology 1385
Open Targets ENSG00000012779 ENSG00000275565
PharmGKB PA46
Reactome R-HSA-2142688 (Synthesis of 5-eicosatetraenoic acids.)
R-HSA-2142691 (Synthesis of Leukotrienes (LT) and Eoxins (EX).)
R-HSA-2142700 (Synthesis of Lipoxins (LX).)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-9012546 (Interleukin-18 signaling.)
UniProt B7ZLS0 E5FPY5 E5FPY7 E5FPY8 P09917 Q5JQ14

Target Cross References - Domain

InterPro IPR000907 (LipOase.)
IPR001024 (PLAT/LH2_dom.)
IPR001885 (LipOase_mml.)
IPR013819 (LipOase_C.)
IPR020833 (LipOase_Fe_BS.)
IPR020834 (LipOase_CS.)
IPR036226 (LipOase_C_sf.)
IPR036392 (PLAT/LH2_dom_sf.)
Pfam PF00305 (Lipoxygenase)
PF01477 (PLAT)

Target Cross References - Structure

PDBe 3O8Y 3V92 3V98 3V99
CREDO 3O8Y 3V92 3V98 3V99