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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL213
Target Type SINGLE PROTEIN
Preferred Name Beta-1 adrenergic receptor
Synonyms ADRB1 | ADRB1R | B1AR | Beta-1 adrenergic receptor | Beta-1 adrenoceptor | Beta-1 adrenoreceptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Beta-1 adrenergic receptor SINGLE PROTEIN P08588

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2097169 Adrenergic receptor beta; ADRB1 & ADRB3 SELECTIVITY GROUP
CHEMBL2096974 Adrenergic receptor beta; ADRB1 & ADRB2 SELECTIVITY GROUP
CHEMBL2094118 Adrenergic receptor beta PROTEIN FAMILY
CHEMBL2331074 Adrenergic receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL24 ATENOLOL Beta-1 adrenergic receptor antagonist 4 DailyMed
CHEMBL499 TIMOLOL Beta-1 adrenergic receptor antagonist 4 DailyMed
CHEMBL500 PINDOLOL Beta-1 adrenergic receptor partial agonist 4 DailyMed
CHEMBL649 NADOLOL Beta-1 adrenergic receptor antagonist 4 DailyMed
CHEMBL1557 DOPAMINE HYDROCHLORIDE Beta-1 adrenergic receptor agonist 4 DailyMed
CHEMBL1671 PROPRANOLOL HYDROCHLORIDE Beta-1 adrenergic receptor antagonist 4 DailyMed
CHEMBL1691 BETAXOLOL HYDROCHLORIDE Beta-1 adrenergic receptor antagonist 4 DailyMed
CHEMBL1700 SOTALOL HYDROCHLORIDE Beta-1 adrenergic receptor antagonist 4 DailyMed
CHEMBL1200337 METOPROLOL SUCCINATE Beta-1 adrenergic receptor antagonist 4 DailyMed
CHEMBL1200363 PENBUTOLOL SULFATE Beta-1 adrenergic receptor antagonist 4 DailyMed FDA
CHEMBL1200418 DOBUTAMINE HYDROCHLORIDE Beta-1 adrenergic receptor agonist 4 DailyMed FDA
CHEMBL1200708 BISOPROLOL FUMARATE Beta-1 adrenergic receptor antagonist 4 DailyMed
CHEMBL1200745 OXPRENOLOL HYDROCHLORIDE Beta-1 adrenergic receptor antagonist 4 ISBN PubMed
CHEMBL1200813 ACEBUTOLOL HYDROCHLORIDE Beta-1 adrenergic receptor antagonist 4 DailyMed
CHEMBL1200837 LEVOBETAXOLOL HYDROCHLORIDE Beta-1 adrenergic receptor antagonist 4 PubMed
CHEMBL1200870 TIMOLOL MALEATE Beta-1 adrenergic receptor antagonist 4 DailyMed
CHEMBL1200898 METOPROLOL FUMARATE Beta-1 adrenergic receptor antagonist 4 DailyMed
CHEMBL1200947 METIPRANOLOL HYDROCHLORIDE Beta-1 adrenergic receptor antagonist 4 DailyMed DailyMed
CHEMBL1201063 PROPAFENONE HYDROCHLORIDE Beta-1 adrenergic receptor antagonist 4 DailyMed
CHEMBL1201115 ESMOLOL HYDROCHLORIDE Beta-1 adrenergic receptor antagonist 4 DailyMed
CHEMBL1201177 LEVOBUNOLOL HYDROCHLORIDE Beta-1 adrenergic receptor antagonist 4 DailyMed
CHEMBL1201731 NEBIVOLOL HYDROCHLORIDE Beta-1 adrenergic receptor antagonist 4 DailyMed
CHEMBL1256957 METOPROLOL TARTRATE Beta-1 adrenergic receptor antagonist 4 DailyMed
CHEMBL2012520 LY377604 Beta-1 adrenergic receptor antagonist 2 PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000043591
Ensembl ENSG00000043591
GO Cellular Component GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004939 (beta-adrenergic receptor activity)
GO:0004940 (beta1-adrenergic receptor activity)
GO:0005057 (receptor signaling protein activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005515 (protein binding)
GO:0030165 (PDZ domain binding)
GO:0031694 (alpha-2A adrenergic receptor binding)
GO:0046982 (protein heterodimerization activity)
GO:0051379 (epinephrine binding)
GO:0051380 (norepinephrine binding)
GO Biological Process GO:0001659 (temperature homeostasis)
GO:0001996 (positive regulation of heart rate by epinephrine-norepinephrine)
GO:0001997 (positive regulation of the force of heart contraction by epinephrine-norepinephrine)
GO:0002024 (diet induced thermogenesis)
GO:0002025 (vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007267 (cell-cell signaling)
GO:0009409 (response to cold)
GO:0030819 (positive regulation of cAMP biosynthetic process)
GO:0031649 (heat generation)
GO:0040015 (negative regulation of multicellular organism growth)
GO:0042596 (fear response)
GO:0043547 (positive regulation of GTPase activity)
GO:0043950 (positive regulation of cAMP-mediated signaling)
GO:0045823 (positive regulation of heart contraction)
GO:0050873 (brown fat cell differentiation)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
Wikipedia Beta-1_adrenergic_receptor

Target Cross References - Protein

canSAR P08588
CGD Beta-blocker response, association with
Human Protein Atlas ENSG00000043591
IntAct P08588
Guide to Pharmacology 28
Open Targets ENSG00000043591
PharmGKB PA38
Pharos P08588 (Tclin)
Reactome R-HSA-390696 (Adrenoceptors.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt B0LPE2 P08588 Q5T5Y4 Q9UKG7 Q9UKG8

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000507 (ADRB1_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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