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Target Report Card

Target Name and Classification

Target ID CHEMBL211
Target Type SINGLE PROTEIN
Preferred Name Muscarinic acetylcholine receptor M2
Synonyms CHRM2 | Muscarinic acetylcholine receptor M2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > acetylcholine receptor

Target Components

Component Description Relationship Accession
Muscarinic acetylcholine receptor M2 SINGLE PROTEIN P08172

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111352 Muscarinic acetylcholine receptor M2 and M5 SELECTIVITY GROUP
CHEMBL2095187 Muscarinic acetylcholine receptors; M2 & M3 SELECTIVITY GROUP
CHEMBL2094109 Muscarinic acetylcholine receptor PROTEIN FAMILY
CHEMBL2111445 Muscarinic acetylcholine receptor M2 and M4 SELECTIVITY GROUP
CHEMBL2095219 Muscarinic acetylcholine receptors; M1 & M2 SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1133 OXYBUTYNIN CHLORIDE Muscarinic acetylcholine receptor M2 antagonist 4 ISBN PubMed PubMed PubMed PubMed
CHEMBL1231 OXYBUTYNIN Muscarinic acetylcholine receptor M2 antagonist 4 ISBN PubMed PubMed PubMed PubMed
CHEMBL1240 PROPANTHELINE BROMIDE Muscarinic acetylcholine receptor M2 antagonist 4 ISBN PubMed PubMed PubMed PubMed PubMed
CHEMBL517712 ATROPINE Muscarinic acetylcholine receptor M2 antagonist 4 FDA ISBN
CHEMBL1768 BETHANECHOL CHLORIDE Muscarinic acetylcholine receptor M2 agonist 4 ISBN PubMed PubMed
CHEMBL1200803 SOLIFENACIN SUCCINATE Muscarinic acetylcholine receptor M2 antagonist 4 ISBN PubMed PubMed
CHEMBL1200935 DARIFENACIN HYDROBROMIDE Muscarinic acetylcholine receptor M2 antagonist 4 DailyMed PubMed
CHEMBL1201765 FESOTERODINE FUMARATE Muscarinic acetylcholine receptor M2 antagonist 4 DailyMed ISBN PubMed PubMed
CHEMBL1722209 TOLTERODINE TARTRATE Muscarinic acetylcholine receptor M2 antagonist 4 DailyMed PubMed
CHEMBL2146146 ATROPINE SULFATE Muscarinic acetylcholine receptor M2 antagonist 4 FDA ISBN
CHEMBL3084748 TROSPIUM CHLORIDE Muscarinic acetylcholine receptor M2 antagonist 4 PubMed PubMed
CHEMBL3039518 BATEFENTEROL Muscarinic acetylcholine receptor M2 antagonist 2 PubMed PubMed
CHEMBL3707249 ASM-024 Muscarinic acetylcholine receptor M2 antagonist 2 PubMed PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000181072
Ensembl ENSG00000181072
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0032279 (asymmetric synapse)
GO:0032280 (symmetric synapse)
GO:0043025 (neuronal cell body)
GO:0043679 (axon terminus)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0008144 (drug binding)
GO:0016907 (G-protein coupled acetylcholine receptor activity)
GO Biological Process GO:0006940 (regulation of smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007197 (adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway)
GO:0007207 (phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway)
GO:0007213 (G-protein coupled acetylcholine receptor signaling pathway)
GO:0007271 (synaptic transmission, cholinergic)
GO:0007399 (nervous system development)
GO:0008016 (regulation of heart contraction)
GO:0009615 (response to virus)
Wikipedia Muscarinic_acetylcholine_receptor_M2

Target Cross References - Protein

canSAR P08172
Human Protein Atlas ENSG00000181072
IntAct P08172
Guide to Pharmacology 14
MICAD NBK23717 (Muscarinic M2 receptor)
Open Targets ENSG00000181072
PharmGKB PA111
Pharos P08172 (Tclin)
Reactome R-HSA-390648 (Muscarinic acetylcholine receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-8856825 (Cargo recognition for clathrin-mediated endocytosis.)
R-HSA-8856828 (Clathrin-mediated endocytosis.)
UniProt P08172 Q4VBK6 Q9P1X9

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000995 (Musac_Ach_rcpt.)
IPR001065 (Musac_Ach_M2_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 3UON 4MQS 4MQT
CREDO 3UON 4MQS 4MQT
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