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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL210
Target Type SINGLE PROTEIN
Preferred Name Beta-2 adrenergic receptor
Synonyms ADRB2 | ADRB2R | B2AR | Beta-2 adrenergic receptor | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Beta-2 adrenergic receptor SINGLE PROTEIN P07550

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111388 Beta-2 adrenergic receptor and beta-3 adrenergic receptor SELECTIVITY GROUP
CHEMBL2096974 Adrenergic receptor beta; ADRB1 & ADRB2 SELECTIVITY GROUP
CHEMBL2094118 Adrenergic receptor beta PROTEIN FAMILY
CHEMBL2331074 Adrenergic receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL499 TIMOLOL Beta-2 adrenergic receptor antagonist 4 DailyMed
CHEMBL500 PINDOLOL Beta-2 adrenergic receptor partial agonist 4 DailyMed
CHEMBL649 NADOLOL Beta-2 adrenergic receptor antagonist 4 DailyMed
CHEMBL714 ALBUTEROL Beta-2 adrenergic receptor agonist 4 DailyMed FDA
CHEMBL1671 PROPRANOLOL HYDROCHLORIDE Beta-2 adrenergic receptor antagonist 4 DailyMed
CHEMBL1700 SOTALOL HYDROCHLORIDE Beta-2 adrenergic receptor antagonist 4 DailyMed
CHEMBL1082607 SALMETEROL XINAFOATE Beta-2 adrenergic receptor agonist 4 DailyMed
CHEMBL1084172 VILANTEROL TRIFENATATE Beta-2 adrenergic receptor agonist 4 FDA
CHEMBL1160544 TERBUTALINE SULFATE Beta-2 adrenergic receptor agonist 4 DailyMed DailyMed
CHEMBL1200363 PENBUTOLOL SULFATE Beta-2 adrenergic receptor antagonist 4 DailyMed FDA
CHEMBL1200405 BITOLTEROL MESYLATE Beta-2 adrenergic receptor agonist 4 PubMed
CHEMBL1200418 DOBUTAMINE HYDROCHLORIDE Beta-2 adrenergic receptor agonist 4 DailyMed FDA
CHEMBL1200444 PIRBUTEROL ACETATE Beta-2 adrenergic receptor agonist 4 DailyMed
CHEMBL1200745 OXPRENOLOL HYDROCHLORIDE Beta-2 adrenergic receptor antagonist 4 ISBN PubMed
CHEMBL1200812 METAPROTERENOL SULFATE Beta-2 adrenergic receptor agonist 4 DailyMed
CHEMBL1200870 TIMOLOL MALEATE Beta-2 adrenergic receptor antagonist 4 DailyMed
CHEMBL1200893 PROTOKYLOL HYDROCHLORIDE Beta-2 adrenergic receptor agonist 4 PubMed
CHEMBL1200920 ISOETHARINE HYDROCHLORIDE Beta-2 adrenergic receptor agonist 4 ISBN
CHEMBL1200947 METIPRANOLOL HYDROCHLORIDE Beta-2 adrenergic receptor antagonist 4 DailyMed DailyMed
CHEMBL1201026 ALBUTEROL SULFATE Beta-2 adrenergic receptor agonist 4 DailyMed FDA
CHEMBL1201061 LEVALBUTEROL HYDROCHLORIDE Beta-2 adrenergic receptor agonist 4 PubMed
CHEMBL1201063 PROPAFENONE HYDROCHLORIDE Beta-2 adrenergic receptor antagonist 4 DailyMed
CHEMBL1201115 ESMOLOL HYDROCHLORIDE Beta-2 adrenergic receptor antagonist 4 DailyMed
CHEMBL1201153 ISOETHARINE MESYLATE Beta-2 adrenergic receptor agonist 4 ISBN
CHEMBL1201160 RITODRINE HYDROCHLORIDE Beta-2 adrenergic receptor agonist 4 ISBN
CHEMBL1201177 LEVOBUNOLOL HYDROCHLORIDE Beta-2 adrenergic receptor antagonist 4 DailyMed
CHEMBL1201731 NEBIVOLOL HYDROCHLORIDE Beta-2 adrenergic receptor antagonist 4 DailyMed
CHEMBL1789842 INDACATEROL MALEATE Beta-2 adrenergic receptor agonist 4 DailyMed
CHEMBL1951071 ARFORMOTEROL TARTRATE Beta-2 adrenergic receptor agonist 4 DailyMed
CHEMBL2062258 LEVALBUTEROL TARTRATE Beta-2 adrenergic receptor agonist 4 PubMed
CHEMBL2105743 OLODATEROL HYDROCHLORIDE Beta-2 adrenergic receptor agonist 4 FDA
CHEMBL2303638 FORMOTEROL FUMARATE DIHYDRATE Beta-2 adrenergic receptor agonist 4 DailyMed DailyMed
CHEMBL1094785 CARMOTEROL Beta-2 adrenergic receptor agonist 2 PubMed PubMed
CHEMBL1940832 MILVETEROL Beta-2 adrenergic receptor agonist 2
CHEMBL2012520 LY377604 Beta-2 adrenergic receptor antagonist 2 PubMed
CHEMBL2218893 BEDORADRINE SULFATE Beta-2 adrenergic receptor agonist 2 Other PubMed
CHEMBL3039518 BATEFENTEROL Beta-2 adrenergic receptor agonist 2 PubMed PubMed
CHEMBL3039530 ABEDITEROL Beta-2 adrenergic receptor agonist 2 PubMed
CHEMBL3545103 AZD3199 Beta-2 adrenergic receptor agonist 2 PubMed
CHEMBL3545087 GSK159802 Beta-2 adrenergic receptor agonist 1
CHEMBL3545272 LAS190792 Beta-2 adrenergic receptor agonist 1 Other Other
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000169252
Ensembl ENSG00000169252
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0032809 (neuronal cell body membrane)
GO:0042383 (sarcolemma)
GO:0043197 (dendritic spine)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0043235 (receptor complex)
GO Molecular Function GO:0001965 (G-protein alpha-subunit binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004941 (beta2-adrenergic receptor activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0008179 (adenylate cyclase binding)
GO:0015459 (potassium channel regulator activity)
GO:0019899 (enzyme binding)
GO:0031713 (B2 bradykinin receptor binding)
GO:0032403 (protein complex binding)
GO:0035240 (dopamine binding)
GO:0035255 (ionotropic glutamate receptor binding)
GO:0042803 (protein homodimerization activity)
GO:0051379 (epinephrine binding)
GO:0051380 (norepinephrine binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0001889 (liver development)
GO:0001993 (regulation of systemic arterial blood pressure by norepinephrine-epinephrine)
GO:0002024 (diet induced thermogenesis)
GO:0002025 (vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure)
GO:0002028 (regulation of sodium ion transport)
GO:0002032 (desensitization of G-protein coupled receptor protein signaling pathway by arrestin)
GO:0002086 (diaphragm contraction)
GO:0003059 (positive regulation of the force of heart contraction by epinephrine)
GO:0006898 (receptor-mediated endocytosis)
GO:0006940 (regulation of smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007171 (activation of transmembrane receptor protein tyrosine kinase activity)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007267 (cell-cell signaling)
GO:0007565 (female pregnancy)
GO:0007568 (aging)
GO:0008284 (positive regulation of cell proliferation)
GO:0008306 (associative learning)
GO:0008333 (endosome to lysosome transport)
GO:0009409 (response to cold)
GO:0010765 (positive regulation of sodium ion transport)
GO:0016525 (negative regulation of angiogenesis)
GO:0030279 (negative regulation of ossification)
GO:0030501 (positive regulation of bone mineralization)
GO:0031398 (positive regulation of protein ubiquitination)
GO:0031649 (heat generation)
GO:0032570 (response to progesterone)
GO:0032781 (positive regulation of ATPase activity)
GO:0033574 (response to testosterone)
GO:0035249 (synaptic transmission, glutamatergic)
GO:0035811 (negative regulation of urine volume)
GO:0040015 (negative regulation of multicellular organism growth)
GO:0042060 (wound healing)
GO:0042312 (regulation of vasodilation)
GO:0043065 (positive regulation of apoptotic process)
GO:0043268 (positive regulation of potassium ion transport)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043627 (response to estrogen)
GO:0044849 (estrous cycle)
GO:0045453 (bone resorption)
GO:0045823 (positive regulation of heart contraction)
GO:0045909 (positive regulation of vasodilation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0045986 (negative regulation of smooth muscle contraction)
GO:0048633 (positive regulation of skeletal muscle tissue growth)
GO:0050728 (negative regulation of inflammatory response)
GO:0050873 (brown fat cell differentiation)
GO:0051924 (regulation of calcium ion transport)
GO:0051930 (regulation of sensory perception of pain)
GO:0060079 (excitatory postsynaptic potential)
GO:0071456 (cellular response to hypoxia)
GO:0071548 (response to dexamethasone)
GO:0071867 (response to monoamine)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
GO:0090331 (negative regulation of platelet aggregation)
GO:0097421 (liver regeneration)
GO:1901098 (positive regulation of autophagosome maturation)
GO:1904504 (positive regulation of lipophagy)
GO:1904925 (positive regulation of mitophagy in response to mitochondrial depolarization)
Wikipedia Beta-2_adrenergic_receptor

Target Cross References - Protein

CGD Beta-2-adrenoreceptor agonist, reduced response to
Human Protein Atlas ENSG00000169252
IntAct P07550
Guide to Pharmacology 29
Open Targets ENSG00000169252
PharmGKB PA39
Pharos P07550 (Tclin)
Reactome R-HSA-390696 (Adrenoceptors.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt B0LPE4 B2R7X2 O14823 O14824 O14825 O14826 P07550 Q4JG18 Q53GA6 Q6GMT4 Q6P4D8 Q8NEQ9 Q96EC3 Q9UCZ0 Q9UCZ1 Q9UCZ2 Q9UCZ3 Q9UH95 Q9UHA1 Q9UMZ5

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000332 (ADRB2_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO 4QKX 5D5A 5D5B
CREDO 1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO 4QKX 5D5A 5D5B
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