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Target Report Card

Target Name and Classification

Target ID CHEMBL2096618
Preferred Name Bcr/Abl fusion protein
Synonyms ABL | ABL1 | Abelson murine leukemia viral oncogene homolog 1 | Abelson tyrosine-protein kinase 1 | JTK7 | Proto-oncogene c-Abl | Tyrosine-protein kinase ABL1 | p150 | BCR | BCR1 | Breakpoint cluster region protein | D22S11 | Renal carcinoma antigen NY-REN-26
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > atypical protein kinase group > atypical protein kinase bcr family
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase abl family
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase ABL1 FUSION PROTEIN P00519
Breakpoint cluster region protein FUSION PROTEIN P11274

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL5146 Breakpoint cluster region protein SINGLE PROTEIN
CHEMBL1862 Tyrosine-protein kinase ABL SINGLE PROTEIN
CHEMBL2111414 Tyrosine-protein kinase ABL PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2105708 PONATINIB HYDROCHLORIDE Bcr/Abl fusion protein inhibitor 4 DailyMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000097007 ENSG00000186716
Ensembl ENSG00000097007 ENSG00000186716
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005739 (mitochondrion)
GO:0031965 (nuclear membrane)
GO:0005829 (cytosol)
GO:0015629 (actin cytoskeleton)
GO:0045211 (postsynaptic membrane)
GO:0016020 (membrane)
GO:0070062 (extracellular exosome)
GO:0005634 (nucleus)
GO:0005730 (nucleolus)
GO:0048471 (perinuclear region of cytoplasm)
GO:0043234 (protein complex)
GO:0005737 (cytoplasm)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0014069 (postsynaptic density)
GO:0030054 (cell junction)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0004515 (nicotinate-nucleotide adenylyltransferase activity)
GO:0016301 (kinase activity)
GO:0005102 (receptor binding)
GO:0005089 (Rho guanyl-nucleotide exchange factor activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0051019 (mitogen-activated protein kinase binding)
GO:0005524 (ATP binding)
GO:0070064 (proline-rich region binding)
GO:0017124 (SH3 domain binding)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005096 (GTPase activator activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0003677 (DNA binding)
GO:0003785 (actin monomer binding)
GO:0004672 (protein kinase activity)
GO:0008022 (protein C-terminus binding)
GO:0019905 (syntaxin binding)
GO:0030145 (manganese ion binding)
GO Biological Process GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030100 (regulation of endocytosis)
GO:0031113 (regulation of microtubule polymerization)
GO:0032956 (regulation of actin cytoskeleton organization)
GO:0042692 (muscle cell differentiation)
GO:0071901 (negative regulation of protein serine/threonine kinase activity)
GO:1904528 (positive regulation of microtubule binding)
GO:0035023 (regulation of Rho protein signal transduction)
GO:0050766 (positive regulation of phagocytosis)
GO:0006281 (DNA repair)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007596 (blood coagulation)
GO:0030155 (regulation of cell adhesion)
GO:0030516 (regulation of axon extension)
GO:0045184 (establishment of protein localization)
GO:0007165 (signal transduction)
GO:0042472 (inner ear morphogenesis)
GO:0034599 (cellular response to oxidative stress)
GO:0051149 (positive regulation of muscle cell differentiation)
GO:0051353 (positive regulation of oxidoreductase activity)
GO:0006468 (protein phosphorylation)
GO:0046777 (protein autophosphorylation)
GO:0051056 (regulation of small GTPase mediated signal transduction)
GO:0030036 (actin cytoskeleton organization)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0042127 (regulation of cell proliferation)
GO:0051444 (negative regulation of ubiquitin-protein transferase activity)
GO:2000145 (regulation of cell motility)
GO:0043114 (regulation of vascular permeability)
GO:0007411 (axon guidance)
GO:0045087 (innate immune response)
GO:0048008 (platelet-derived growth factor receptor signaling pathway)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:1900275 (negative regulation of phospholipase C activity)
GO:1904531 (positive regulation of actin filament binding)
GO:2001020 (regulation of response to DNA damage stimulus)
GO:0051726 (regulation of cell cycle)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006914 (autophagy)
GO:0030154 (cell differentiation)
GO:0043065 (positive regulation of apoptotic process)
GO:0051882 (mitochondrial depolarization)
GO:2000249 (regulation of actin cytoskeleton reorganization)
GO:0043547 (positive regulation of GTPase activity)
GO:0050728 (negative regulation of inflammatory response)
GO:0050885 (neuromuscular process controlling balance)
GO:0000724 (double-strand break repair via homologous recombination)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006298 (mismatch repair)
GO:0006464 (cellular protein modification process)
GO:0006975 (DNA damage induced protein phosphorylation)
GO:0007155 (cell adhesion)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0010506 (regulation of autophagy)
GO:0035791 (platelet-derived growth factor receptor-beta signaling pathway)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:1903351 (cellular response to dopamine)
GO:0043314 (negative regulation of neutrophil degranulation)
GO:0060313 (negative regulation of blood vessel remodeling)
GO:0006302 (double-strand break repair)
GO:0006979 (response to oxidative stress)
GO:0007050 (cell cycle arrest)
GO:0007067 (mitotic nuclear division)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007264 (small GTPase mediated signal transduction)
GO:0016477 (cell migration)
GO:0042770 (signal transduction in response to DNA damage)
GO:0002692 (negative regulation of cellular extravasation)
GO:0007420 (brain development)
GO:0032496 (response to lipopolysaccharide)
Wikipedia BCR_(gene) ABL_(gene)

Target Cross References - Protein

canSAR P00519 P11274
CGD CML treatment, response to
Human Protein Atlas ENSG00000097007 ENSG00000186716
IntAct P00519
Guide to Pharmacology 1923 (ABL proto-oncogene 1, non-receptor tyrosine kinase)
2755 (breakpoint cluster region)
PharmGKB PA24413
UniProt P00519 Q13869 Q16133 Q4LE80 Q45F09 A3KFJ3 Q13870 Q12842 Q6NZI3 Q17R61 P11274 P78501

Target Cross References - Domain

InterPro IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR000198 (RhoGAP_dom.)
IPR001849 (PH_domain.)
IPR011993 (PH/PTB_dom.)
IPR015123 (Bcr-Abl_oncoprot_oligo.)
IPR000219 (DH-domain.)
IPR008936 (Rho_GTPase_activation_prot.)
IPR000719 (Prot_kinase_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR015015 (F-actin_binding.)
IPR008266 (Tyr_kinase_AS.)
IPR000008 (C2_dom.)
IPR011009 (Kinase-like_dom.)
IPR001331 (GDS_CDC24_CS.)
Pfam PF00018 (SH3_1)
PF08919 (F_actin_bind)
PF00620 (RhoGAP)
PF09036 (Bcr-Abl_Oligo)
PF00621 (RhoGEF)
PF07714 (Pkinase_Tyr)
PF00168 (C2)
PF00017 (SH2)

Target Cross References - Structure

PDBe 4JJB 4JJD 2HZI 3EG2 3PYY 3QRI 4JJC 1BBZ 2F4J 2V7A 3EG0 2G2I 2O88 3EGU 3UE4 4J9B 4J9F 4J9G 1K1F 1OPL 2HYY 3EG1 4J9C 4J9D More...
CREDO 4JJB 4JJD 2HZI 3EG2 3PYY 3QRI 4JJC 1BBZ 2F4J 2V7A 3EG0 2G2I 2O88 3EGU 3UE4 4J9B 4J9F 4J9G 1K1F 1OPL 2HYY 3EG1 4J9C 4J9D More...