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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2096618
Target Type CHIMERIC PROTEIN
Preferred Name Bcr/Abl fusion protein
Synonyms ABL | ABL1 | Abelson murine leukemia viral oncogene homolog 1 | Abelson tyrosine-protein kinase 1 | JTK7 | Proto-oncogene c-Abl | Tyrosine-protein kinase ABL1 | p150 | BCR | BCR1 | Breakpoint cluster region protein | D22S11 | Renal carcinoma antigen NY-REN-26
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > atypical protein kinase group > atypical protein kinase bcr family
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase abl family
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase ABL1 FUSION PROTEIN P00519
Breakpoint cluster region protein FUSION PROTEIN P11274

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL5146 Breakpoint cluster region protein SINGLE PROTEIN
CHEMBL1862 Tyrosine-protein kinase ABL SINGLE PROTEIN
CHEMBL2111414 Tyrosine-protein kinase ABL PROTEIN FAMILY

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL2105708 PONATINIB HYDROCHLORIDE Bcr/Abl fusion protein inhibitor DailyMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Protein

CGD CML treatment, response to
Guide to Pharmacology 1923 (ABL proto-oncogene 1, non-receptor tyrosine kinase)
2755 (breakpoint cluster region)
PharmGKB PA24413
PA25321
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