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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2074
Target Type SINGLE PROTEIN
Preferred Name Maltase-glucoamylase
Synonyms Alpha-glucosidase | Glucan 1,4-alpha-glucosidase | Glucoamylase | MGA | MGAM | MGAML | Maltase | Maltase-glucoamylase, intestinal
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Maltase-glucoamylase, intestinal SINGLE PROTEIN O43451

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3833502 Alpha glucosidase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1561 MIGLITOL Maltase-glucoamylase inhibitor 4 DailyMed PubMed
CHEMBL1566 ACARBOSE Maltase-glucoamylase inhibitor 4 DailyMed InterPro

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000257335
Ensembl ENSG00000257335
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0070062 (extracellular exosome)
GO:0070821 (tertiary granule membrane)
GO:0101003 (ficolin-1-rich granule membrane)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004339 (glucan 1,4-alpha-glucosidase activity)
GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds)
GO:0004558 (alpha-1,4-glucosidase activity)
GO:0016160 (amylase activity)
GO:0016787 (hydrolase activity)
GO:0016798 (hydrolase activity, acting on glycosyl bonds)
GO:0030246 (carbohydrate binding)
GO:0032450 (maltose alpha-glucosidase activity)
GO:0090599 (alpha-glucosidase activity)
GO Biological Process GO:0000023 (maltose metabolic process)
GO:0005975 (carbohydrate metabolic process)
GO:0005983 (starch catabolic process)
GO:0008152 (metabolic process)
GO:0043312 (neutrophil degranulation)
GO:0044245 (polysaccharide digestion)
Wikipedia Maltase-glucoamylase

Target Cross References - Protein

canSAR O43451
Human Protein Atlas ENSG00000257335
IntAct O43451
Guide to Pharmacology 2627
Open Targets ENSG00000257335
PharmGKB PA30778
Reactome R-HSA-189085 (Digestion of dietary carbohydrate.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt O43451 Q0VAX6 Q75ME7 Q86UM5

Target Cross References - Domain

InterPro IPR000322 (Glyco_hydro_31.)
IPR000519 (P_trefoil_dom.)
IPR011013 (Gal_mutarotase_sf_dom.)
IPR013780 (Glyco_hydro_b.)
IPR017853 (Glycoside_hydrolase_SF.)
IPR017957 (P_trefoil_CS.)
IPR030458 (Glyco_hydro_31_AS.)
IPR030459 (Glyco_hydro_31_CS.)
IPR031727 (Gal_mutarotase_N.)
Pfam PF00088 (Trefoil)
PF01055 (Glyco_hydro_31)
PF16863 (NtCtMGAM_N)

Target Cross References - Structure

PDBe 2QLY 2QMJ 3CTT 3L4T 3L4U 3L4V 3L4W 3L4X 3L4Y 3L4Z 3TON 3TOP
CREDO 2QLY 2QMJ 3CTT 3L4T 3L4U 3L4V 3L4W 3L4X 3L4Y 3L4Z 3TON 3TOP
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