ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2071
Target Type SINGLE PROTEIN
Preferred Name Sulfonylurea receptor 1
Synonyms ABCC8 | ATP-binding cassette sub-family C member 8 | HRINS | SUR | SUR1 | Sulfonylurea receptor 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > atp-binding cassette > abcc subfamily

Target Components

Component Description Relationship Accession
ATP-binding cassette sub-family C member 8 SINGLE PROTEIN Q09428

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095152 Sulfonylurea receptors; K-ATP channels PROTEIN COMPLEX GROUP
CHEMBL2096972 Sulfonylurea receptor 1, Kir6.2 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000006071
Ensembl ENSG00000006071
GO Cellular Component GO:0005886 (plasma membrane)
GO:0008076 (voltage-gated potassium channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030672 (synaptic vesicle membrane)
GO:0042383 (sarcolemma)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005267 (potassium channel activity)
GO:0005524 (ATP binding)
GO:0008281 (sulfonylurea receptor activity)
GO:0015272 (ATP-activated inward rectifier potassium channel activity)
GO:0016887 (ATPase activity)
GO:0019905 (syntaxin binding)
GO:0042626 (ATPase activity, coupled to transmembrane movement of substances)
GO:0043225 (anion transmembrane-transporting ATPase activity)
GO:0044325 (ion channel binding)
GO Biological Process GO:0006810 (transport)
GO:0006813 (potassium ion transport)
GO:0007165 (signal transduction)
GO:0009268 (response to pH)
GO:0010043 (response to zinc ion)
GO:0032496 (response to lipopolysaccharide)
GO:0032868 (response to insulin)
GO:0042493 (response to drug)
GO:0043268 (positive regulation of potassium ion transport)
GO:0046676 (negative regulation of insulin secretion)
GO:0050796 (regulation of insulin secretion)
GO:0055085 (transmembrane transport)
GO:0071310 (cellular response to organic substance)
GO:0071805 (potassium ion transmembrane transport)
GO:0098656 (anion transmembrane transport)
Wikipedia ABCC8

Target Cross References - Protein

CGD Diabetes mellitus, transient neonatal, 2; Diabetes, permanent neonatal; Hyperinsulinemic hypoglycemia, familial, 1; Hypoglycemia, leucine-induced
Human Protein Atlas ENSG00000006071
Guide to Pharmacology 2594
Open Targets ENSG00000006071
PharmGKB PA24395
Reactome R-HSA-1296025 (ATP sensitive Potassium channels.)
R-HSA-382556 (ABC-family proteins mediated transport.)
R-HSA-422356 (Regulation of insulin secretion.)
R-HSA-5683177 (Defective ABCC8 can cause hypoglycemias and hyperglycemias.)
UniProt A6NMX8 E3UYX6 O75948 Q09428 Q16583

Target Cross References - Domain

InterPro IPR000388 (Sulphorea_rcpt.)
IPR000844 (ABCC8.)
IPR003439 (ABC_transporter-like.)
IPR003593 (AAA+_ATPase.)
IPR011527 (ABC1_TM_dom.)
IPR017871 (ABC_transporter_CS.)
IPR027417 (P-loop_NTPase.)
Pfam PF00005 (ABC_tran)
PF00664 (ABC_membrane)
spacer
spacer