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Target Report Card

Target Name and Classification

Target ID CHEMBL2068
Preferred Name Ephrin type-A receptor 2
Synonyms ECK | EPHA2 | Ephrin type-A receptor 2 | Epithelial cell kinase | Tyrosine-protein kinase receptor ECK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase eph family

Target Components

Component Description Relationship Accession
Ephrin type-A receptor 2 SINGLE PROTEIN P29317

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363043 Ephrin receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1421 DASATINIB Ephrin type-A receptor 2 inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000142627
Ensembl ENSG00000142627
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005925 (focal adhesion)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030027 (lamellipodium)
GO:0030054 (cell junction)
GO:0031256 (leading edge membrane)
GO:0031258 (lamellipodium membrane)
GO:0032587 (ruffle membrane)
GO:0042995 (cell projection)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001618 (virus receptor activity)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005003 (ephrin receptor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0045296 (cadherin binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001649 (osteoblast differentiation)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007155 (cell adhesion)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007275 (multicellular organism development)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0010591 (regulation of lamellipodium assembly)
GO:0016032 (viral process)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030154 (cell differentiation)
GO:0030216 (keratinocyte differentiation)
GO:0030316 (osteoclast differentiation)
GO:0033598 (mammary gland epithelial cell proliferation)
GO:0033628 (regulation of cell adhesion mediated by integrin)
GO:0043491 (protein kinase B signaling)
GO:0043535 (regulation of blood vessel endothelial cell migration)
GO:0045765 (regulation of angiogenesis)
GO:0046058 (cAMP metabolic process)
GO:0046718 (viral entry into host cell)
GO:0046849 (bone remodeling)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048870 (cell motility)
GO:0051898 (negative regulation of protein kinase B signaling)
GO:0060326 (cell chemotaxis)
GO:0060444 (branching involved in mammary gland duct morphogenesis)
GO:0070309 (lens fiber cell morphogenesis)
GO:0070372 (regulation of ERK1 and ERK2 cascade)
GO:0070848 (response to growth factor)
GO:0090630 (activation of GTPase activity)
GO:1903078 (positive regulation of protein localization to plasma membrane)
Wikipedia EPH_receptor_A2

Target Cross References - Protein

canSAR P29317
CGD Cataract, age-related cortical, 2; Cataract, posterior polar, 1
Human Protein Atlas ENSG00000142627
IntAct P29317
Guide to Pharmacology 1822
Open Targets ENSG00000142627
PharmGKB PA27818
Pharos P29317 (Tclin)
Reactome R-HSA-2682334 (EPH-Ephrin signaling.)
R-HSA-3928663 (EPHA-mediated growth cone collapse.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
UniProt B5A968 P29317 Q8N3Z2

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001090 (Ephrin_rcpt_lig-bd_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001426 (Tyr_kinase_rcpt_V_CS.)
IPR001660 (SAM.)
IPR003961 (FN3_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR008979 (Galactose-bd-like_sf.)
IPR009030 (Growth_fac_rcpt_cys_sf.)
IPR011009 (Kinase-like_dom_sf.)
IPR011641 (Tyr-kin_ephrin_A/B_rcpt-like.)
IPR013761 (SAM/pointed_sf.)
IPR013783 (Ig-like_fold.)
IPR016257 (Tyr_kinase_ephrin_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR027936 (Eph_TM.)
IPR034263 (EphA2_rcpt_lig-bd.)
IPR036116 (FN3_sf.)
Pfam PF00041 (fn3)
PF00536 (SAM_1)
PF01404 (Ephrin_lbd)
PF07714 (Pkinase_Tyr)
PF14575 (EphA2_TM)

Target Cross References - Structure

PDBe 1MQB 2X10 2X11 3C8X 3CZU 3FL7 3HEI 3HPN 3KKA 3MBW 3MX0 3SKJ 4P2K 4PDO 4TRL 5EK7 5I9U 5I9V 5I9W 5I9X 5I9Y 5I9Z 5IA0 5IA1 More...
CREDO 1MQB 2X10 2X11 3C8X 3CZU 3FL7 3HEI 3HPN 3KKA 3MBW 3MX0 3SKJ 4P2K 4PDO 4TRL 5EK7 5I9U 5I9V 5I9W 5I9X 5I9Y 5I9Z 5IA0 5IA1 More...