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Target Report Card

Target Name and Classification

Target ID CHEMBL2056
Target Type SINGLE PROTEIN
Preferred Name Dopamine D1 receptor
Synonyms D(1A) dopamine receptor | DRD1 | Dopamine D1 receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > dopamine receptor

Target Components

Component Description Relationship Accession
D(1A) dopamine receptor SINGLE PROTEIN P21728

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111341 Dopamine D1 and D2 receptor SELECTIVITY GROUP
CHEMBL2096905 Dopamine receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1026 FENOLDOPAM MESYLATE Dopamine D1 receptor agonist 4 DailyMed
CHEMBL1200843 METHYLERGONOVINE MALEATE Dopamine D1 receptor antagonist 4 PubMed PubMed
CHEMBL298406 ECOPIPAM Dopamine D1 receptor antagonist 3 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000184845
Ensembl ENSG00000184845
GO Cellular Component GO:0005634 (nucleus)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0012505 (endomembrane system)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0060170 (ciliary membrane)
GO:0097730 (non-motile cilium)
GO Molecular Function GO:0001588 (dopamine neurotransmitter receptor activity, coupled via Gs)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004952 (dopamine neurotransmitter receptor activity)
GO:0005515 (protein binding)
GO:0035240 (dopamine binding)
GO Biological Process GO:0001659 (temperature homeostasis)
GO:0001661 (conditioned taste aversion)
GO:0001662 (behavioral fear response)
GO:0001932 (regulation of protein phosphorylation)
GO:0001963 (synaptic transmission, dopaminergic)
GO:0001975 (response to amphetamine)
GO:0006606 (protein import into nucleus)
GO:0006936 (muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007191 (adenylate cyclase-activating dopamine receptor signaling pathway)
GO:0007212 (dopamine receptor signaling pathway)
GO:0007416 (synapse assembly)
GO:0007612 (learning)
GO:0007613 (memory)
GO:0007617 (mating behavior)
GO:0007625 (grooming behavior)
GO:0007626 (locomotory behavior)
GO:0007628 (adult walking behavior)
GO:0007631 (feeding behavior)
GO:0008306 (associative learning)
GO:0008542 (visual learning)
GO:0010628 (positive regulation of gene expression)
GO:0014002 (astrocyte development)
GO:0015872 (dopamine transport)
GO:0019226 (transmission of nerve impulse)
GO:0019228 (neuronal action potential)
GO:0021542 (dentate gyrus development)
GO:0021756 (striatum development)
GO:0021766 (hippocampus development)
GO:0021853 (cerebral cortex GABAergic interneuron migration)
GO:0030335 (positive regulation of cell migration)
GO:0030432 (peristalsis)
GO:0035106 (operant conditioning)
GO:0042053 (regulation of dopamine metabolic process)
GO:0042220 (response to cocaine)
GO:0042311 (vasodilation)
GO:0042417 (dopamine metabolic process)
GO:0042493 (response to drug)
GO:0042711 (maternal behavior)
GO:0043268 (positive regulation of potassium ion transport)
GO:0043987 (histone H3-S10 phosphorylation)
GO:0046323 (glucose import)
GO:0046959 (habituation)
GO:0046960 (sensitization)
GO:0048148 (behavioral response to cocaine)
GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol)
GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway)
GO:0051584 (regulation of dopamine uptake involved in synaptic transmission)
GO:0051968 (positive regulation of synaptic transmission, glutamatergic)
GO:0060134 (prepulse inhibition)
GO:0060158 (phospholipase C-activating dopamine receptor signaling pathway)
GO:0060291 (long-term synaptic potentiation)
GO:0060292 (long term synaptic depression)
GO:0071870 (cellular response to catecholamine stimulus)
GO:1903351 (cellular response to dopamine)
Wikipedia Dopamine_receptor_D1

Target Cross References - Protein

canSAR P21728
Human Protein Atlas ENSG00000184845
Guide to Pharmacology 214
MICAD NBK23009 (D1 dopamine receptors)
NBK23252 (Dopamine D1 receptor)
Open Targets ENSG00000184845
PharmGKB PA147
Pharos P21728 (Tclin)
Reactome R-HSA-390651 (Dopamine receptors.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt B2RA44 P21728 Q4QRJ0

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000929 (Dopamine_rcpt.)
IPR001413 (Dopamine_D1_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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