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Target Report Card

Target Name and Classification

Target ID CHEMBL2055
Preferred Name Retinoic acid receptor alpha
Synonyms NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | RARA | Retinoic acid receptor alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group b > nuclear hormone receptor subfamily 1 group b member 1

Target Components

Component Description Relationship Accession
Retinoic acid receptor alpha SINGLE PROTEIN P10276

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363069 Retinoic acid receptor PROTEIN FAMILY
CHEMBL2363072 Retinoid X receptor gamma/retinoic acid receptor alpha PROTEIN COMPLEX
CHEMBL2363071 Retinoid receptor PROTEIN FAMILY
CHEMBL3430883 Retinoic acid receptor alpha/Retinoid X receptor alpha PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL107430 NRX195183 Retinoic acid receptor alpha agonist 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131759
Ensembl ENSG00000131759
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0009986 (cell surface)
GO:0015629 (actin cytoskeleton)
GO:0030425 (dendrite)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000900 (translation repressor activity, nucleic acid binding)
GO:0000975 (regulatory region DNA binding)
GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0001012 (RNA polymerase II regulatory region DNA binding)
GO:0001972 (retinoic acid binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003708 (retinoic acid receptor activity)
GO:0003713 (transcription coactivator activity)
GO:0003714 (transcription corepressor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0008144 (drug binding)
GO:0008270 (zinc ion binding)
GO:0019899 (enzyme binding)
GO:0019904 (protein domain specific binding)
GO:0031490 (chromatin DNA binding)
GO:0042826 (histone deacetylase binding)
GO:0043422 (protein kinase B binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0044323 (retinoic acid-responsive element binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0048027 (mRNA 5'-UTR binding)
GO:0051018 (protein kinase A binding)
GO:0051393 (alpha-actinin binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001657 (ureteric bud development)
GO:0001843 (neural tube closure)
GO:0001889 (liver development)
GO:0002068 (glandular epithelial cell development)
GO:0003148 (outflow tract septum morphogenesis)
GO:0003417 (growth plate cartilage development)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007281 (germ cell development)
GO:0007283 (spermatogenesis)
GO:0007565 (female pregnancy)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0008584 (male gonad development)
GO:0010628 (positive regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0017148 (negative regulation of translation)
GO:0021766 (hippocampus development)
GO:0030850 (prostate gland development)
GO:0030852 (regulation of granulocyte differentiation)
GO:0030853 (negative regulation of granulocyte differentiation)
GO:0031076 (embryonic camera-type eye development)
GO:0031641 (regulation of myelination)
GO:0032355 (response to estradiol)
GO:0032526 (response to retinoic acid)
GO:0032689 (negative regulation of interferon-gamma production)
GO:0032720 (negative regulation of tumor necrosis factor production)
GO:0032736 (positive regulation of interleukin-13 production)
GO:0032753 (positive regulation of interleukin-4 production)
GO:0032754 (positive regulation of interleukin-5 production)
GO:0033189 (response to vitamin A)
GO:0034097 (response to cytokine)
GO:0035264 (multicellular organism growth)
GO:0042981 (regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043277 (apoptotic cell clearance)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045471 (response to ethanol)
GO:0045596 (negative regulation of cell differentiation)
GO:0045630 (positive regulation of T-helper 2 cell differentiation)
GO:0045666 (positive regulation of neuron differentiation)
GO:0045787 (positive regulation of cell cycle)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0045947 (negative regulation of translational initiation)
GO:0048167 (regulation of synaptic plasticity)
GO:0048384 (retinoic acid receptor signaling pathway)
GO:0051099 (positive regulation of binding)
GO:0055012 (ventricular cardiac muscle cell differentiation)
GO:0060010 (Sertoli cell fate commitment)
GO:0060173 (limb development)
GO:0060324 (face development)
GO:0060348 (bone development)
GO:0060534 (trachea cartilage development)
GO:0060591 (chondroblast differentiation)
GO:0061037 (negative regulation of cartilage development)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071300 (cellular response to retinoic acid)
GO:0071391 (cellular response to estrogen stimulus)
Wikipedia Retinoic_acid_receptor_alpha

Target Cross References - Protein

canSAR P10276
Human Protein Atlas ENSG00000131759
IntAct P10276
Guide to Pharmacology 590
Open Targets ENSG00000131759
PharmGKB PA34225
Pharos P10276 (Tclin)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
R-HSA-5362517 (Signaling by Retinoic Acid.)
R-HSA-5617472 (Activation of anterior HOX genes in hindbrain development during early embryogenesis.)
UniProt B8Y636 P10276 P78456 Q13440 Q13441 Q96S41 Q9NQS0

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR003078 (Retinoic_acid_rcpt.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure