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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2055
Target Type SINGLE PROTEIN
Preferred Name Retinoic acid receptor alpha
Synonyms NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | RARA | Retinoic acid receptor alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group b > nuclear hormone receptor subfamily 1 group b member 1

Target Components

Component Description Relationship Accession
Retinoic acid receptor alpha SINGLE PROTEIN P10276

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363069 Retinoic acid receptor PROTEIN FAMILY
CHEMBL2363071 Retinoid receptor PROTEIN FAMILY
CHEMBL2363072 Retinoid X receptor gamma/retinoic acid receptor alpha PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000131759
Ensembl ENSG00000131759
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0001972 (retinoic acid binding)
GO:0003700 (sequence-specific DNA binding transcription factor activity)
GO:0003707 (steroid hormone receptor activity)
GO:0003708 (retinoic acid receptor activity)
GO:0003713 (transcription coactivator activity)
GO:0003714 (transcription corepressor activity)
GO:0005102 (receptor binding)
GO:0008270 (zinc ion binding)
GO:0016563 (transcription activator activity)
GO:0019899 (enzyme binding)
GO:0019904 (protein domain specific binding)
GO:0031490 (chromatin DNA binding)
GO:0044323 (retinoic acid-responsive element binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0008284 (positive regulation of cell proliferation)
GO:0030520 (estrogen receptor signaling pathway)
GO:0030853 (negative regulation of granulocyte differentiation)
GO:0032355 (response to estradiol stimulus)
GO:0032689 (negative regulation of interferon-gamma production)
GO:0032720 (negative regulation of tumor necrosis factor production)
GO:0032736 (positive regulation of interleukin-13 production)
GO:0032753 (positive regulation of interleukin-4 production)
GO:0032754 (positive regulation of interleukin-5 production)
GO:0034339 (regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor)
GO:0043277 (apoptotic cell clearance)
GO:0045630 (positive regulation of T-helper 2 cell differentiation)
GO:0045787 (positive regulation of cell cycle)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0051099 (positive regulation of binding)
GO:0071300 (cellular response to retinoic acid)
GO:0071391 (cellular response to estrogen stimulus)
Wikipedia Retinoic_acid_receptor_alpha

Target Cross References - Protein

canSAR P10276
Human Protein Atlas ENSG00000131759
IntAct P10276
Guide to Pharmacology 590 (Retinoic acid receptor-Alpha;)
PharmGKB PA34225
Reactome REACT_71 (Gene Expression.)
UniProt P10276 P78456 Q13440 Q13441 Q96S41 Q9NQS0

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd_core.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Str_hrmn_rcpt.)
IPR003078 (Retinoic_acid_rcpt.)
IPR008946 (Nucl_hormone_rcpt_ligand-bd.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1DKF 1DSZ 3A9E 3KMR 3KMZ
CREDO 1DKF 1DSZ 3A9E 3KMR 3KMZ
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