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Target Report Card

Target Name and Classification

Target ID CHEMBL2055
Preferred Name Retinoic acid receptor alpha
Synonyms NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | RARA | Retinoic acid receptor alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group b > nuclear hormone receptor subfamily 1 group b member 1

Target Components

Component Description Relationship Accession
Retinoic acid receptor alpha SINGLE PROTEIN P10276

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363069 Retinoic acid receptor PROTEIN FAMILY
CHEMBL2363071 Retinoid receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL107430 NRX195183 Retinoic acid receptor alpha agonist 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131759
Ensembl ENSG00000131759
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0009986 (cell surface)
GO:0015629 (actin cytoskeleton)
GO:0030425 (dendrite)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000900 (translation repressor activity, nucleic acid binding)
GO:0000975 (regulatory region DNA binding)
GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0001012 (RNA polymerase II regulatory region DNA binding)
GO:0001972 (retinoic acid binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003708 (retinoic acid receptor activity)
GO:0003713 (transcription coactivator activity)
GO:0003714 (transcription corepressor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0008144 (drug binding)
GO:0008270 (zinc ion binding)
GO:0019899 (enzyme binding)
GO:0019904 (protein domain specific binding)
GO:0031490 (chromatin DNA binding)
GO:0042826 (histone deacetylase binding)
GO:0043422 (protein kinase B binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0044323 (retinoic acid-responsive element binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0048027 (mRNA 5'-UTR binding)
GO:0051018 (protein kinase A binding)
GO:0051393 (alpha-actinin binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001657 (ureteric bud development)
GO:0001843 (neural tube closure)
GO:0001889 (liver development)
GO:0002068 (glandular epithelial cell development)
GO:0003148 (outflow tract septum morphogenesis)
GO:0003417 (growth plate cartilage development)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007281 (germ cell development)
GO:0007283 (spermatogenesis)
GO:0007565 (female pregnancy)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0008584 (male gonad development)
GO:0010628 (positive regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0017148 (negative regulation of translation)
GO:0021766 (hippocampus development)
GO:0030850 (prostate gland development)
GO:0030852 (regulation of granulocyte differentiation)
GO:0030853 (negative regulation of granulocyte differentiation)
GO:0031076 (embryonic camera-type eye development)
GO:0031641 (regulation of myelination)
GO:0032355 (response to estradiol)
GO:0032526 (response to retinoic acid)
GO:0032689 (negative regulation of interferon-gamma production)
GO:0032720 (negative regulation of tumor necrosis factor production)
GO:0032736 (positive regulation of interleukin-13 production)
GO:0032753 (positive regulation of interleukin-4 production)
GO:0032754 (positive regulation of interleukin-5 production)
GO:0033189 (response to vitamin A)
GO:0034097 (response to cytokine)
GO:0035264 (multicellular organism growth)
GO:0042981 (regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043277 (apoptotic cell clearance)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045471 (response to ethanol)
GO:0045596 (negative regulation of cell differentiation)
GO:0045630 (positive regulation of T-helper 2 cell differentiation)
GO:0045666 (positive regulation of neuron differentiation)
GO:0045787 (positive regulation of cell cycle)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0045947 (negative regulation of translational initiation)
GO:0048167 (regulation of synaptic plasticity)
GO:0048384 (retinoic acid receptor signaling pathway)
GO:0051099 (positive regulation of binding)
GO:0055012 (ventricular cardiac muscle cell differentiation)
GO:0060010 (Sertoli cell fate commitment)
GO:0060173 (limb development)
GO:0060324 (face development)
GO:0060348 (bone development)
GO:0060534 (trachea cartilage development)
GO:0060591 (chondroblast differentiation)
GO:0061037 (negative regulation of cartilage development)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071300 (cellular response to retinoic acid)
GO:0071391 (cellular response to estrogen stimulus)
Wikipedia Retinoic_acid_receptor_alpha

Target Cross References - Protein

canSAR P10276
Human Protein Atlas ENSG00000131759
IntAct P10276
Guide to Pharmacology 590
Open Targets ENSG00000131759
PharmGKB PA34225
Pharos P10276 (Tclin)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
R-HSA-5362517 (Signaling by Retinoic Acid.)
R-HSA-5617472 (Activation of anterior HOX genes in hindbrain development during early embryogenesis.)
UniProt B8Y636 P10276 P78456 Q13440 Q13441 Q96S41 Q9NQS0

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR003078 (Retinoic_acid_rcpt.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure