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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2046261
Preferred Name Prostaglandin E synthase
Synonyms Microsomal prostaglandin E synthase 1 | Pges | Prostaglandin E synthase | Ptges | mPGES-1
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Prostaglandin E synthase SINGLE PROTEIN Q9JM51

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005641 (nuclear envelope lumen)
GO:0005737 (cytoplasm)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0004667 (prostaglandin-D synthase activity)
GO:0016853 (isomerase activity)
GO:0043295 (glutathione binding)
GO:0050220 (prostaglandin-E synthase activity)
GO Biological Process GO:0001516 (prostaglandin biosynthetic process)
GO:0002526 (acute inflammatory response)
GO:0002544 (chronic inflammatory response)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006693 (prostaglandin metabolic process)
GO:0008285 (negative regulation of cell proliferation)
GO:0014070 (response to organic cyclic compound)
GO:0032496 (response to lipopolysaccharide)
GO:0032526 (response to retinoic acid)
GO:0034097 (response to cytokine)
GO:0051592 (response to calcium ion)

Target Cross References - Protein

Reactome R-MMU-2162123 (Synthesis of Prostaglandins (PG) and Thromboxanes (TX).)
UniProt Q3T9C5 Q9JM51

Target Cross References - Domain

InterPro IPR001129 (Membr-assoc_MAPEG.)
IPR023352 (MAPEG-like_dom_sf.)
Pfam PF01124 (MAPEG)