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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2035
Target Type SINGLE PROTEIN
Preferred Name Muscarinic acetylcholine receptor M5
Synonyms CHRM5 | Muscarinic acetylcholine receptor M5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > acetylcholine receptor

Target Components

Component Description Relationship Accession
Muscarinic acetylcholine receptor M5 SINGLE PROTEIN P08912

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111352 Muscarinic acetylcholine receptor M2 and M5 SELECTIVITY GROUP
CHEMBL2094109 Muscarinic acetylcholine receptor PROTEIN FAMILY
CHEMBL2111417 Muscarinic acetylcholine receptor M1/M5 chimeric protein CHIMERIC PROTEIN

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000184984
Ensembl ENSG00000184984
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004435 (phosphatidylinositol phospholipase C activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0016907 (G-protein coupled acetylcholine receptor activity)
GO Biological Process GO:0001696 (gastric acid secretion)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007197 (adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway)
GO:0007207 (phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway)
GO:0007213 (G-protein coupled acetylcholine receptor signaling pathway)
GO:0007271 (synaptic transmission, cholinergic)
GO:0008283 (cell proliferation)
GO:0015872 (dopamine transport)
GO:0019226 (transmission of nerve impulse)
GO:0060304 (regulation of phosphatidylinositol dephosphorylation)
Wikipedia Muscarinic_acetylcholine_receptor_M5

Target Cross References - Protein

canSAR P08912
Human Protein Atlas ENSG00000184984
Guide to Pharmacology 17
Open Targets ENSG00000184984
PharmGKB PA26486
Pharos P08912 (Tclin)
Reactome R-HSA-390648 (Muscarinic acetylcholine receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
UniProt P08912 Q96RG7

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000502 (Musac_Ach_M5_rcpt.)
IPR000995 (Musac_Ach_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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