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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2034800
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase receptor Tie-1
Synonyms Tie | Tie-1 | Tie1 | Tyrosine-protein kinase receptor Tie-1
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase tie family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase receptor Tie-1 SINGLE PROTEIN Q06806

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001568 (blood vessel development)
GO:0001570 (vasculogenesis)
GO:0001701 (in utero embryonic development)
GO:0006468 (protein phosphorylation)
GO:0016310 (phosphorylation)
GO:0016525 (negative regulation of angiogenesis)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030336 (negative regulation of cell migration)
GO:0032526 (response to retinoic acid)
GO:0045026 (plasma membrane fusion)

Target Cross References - Protein

IntAct Q06806
UniProt Q06806 Q811F4 Q8BGI2

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000742 (EGF-like_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR003599 (Ig_sub.)
IPR003961 (FN3_dom.)
IPR007110 (Ig-like_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013032 (EGF-like_CS.)
IPR013151 (Immunoglobulin.)
IPR013783 (Ig-like_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF00041 (fn3)
PF00047 (ig)
PF07714 (Pkinase_Tyr)
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