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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL203
Target Type SINGLE PROTEIN
Preferred Name Epidermal growth factor receptor erbB1
Synonyms EGFR | ERBB | ERBB1 | Epidermal growth factor receptor | HER1 | Proto-oncogene c-ErbB-1 | Receptor tyrosine-protein kinase erbB-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase egfr family

Target Components

Component Description Relationship Accession
Epidermal growth factor receptor SINGLE PROTEIN P00533

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363049 Epidermal growth factor receptor PROTEIN FAMILY
CHEMBL2111431 Epidermal growth factor receptor and ErbB2 (HER1 and HER2) PROTEIN FAMILY

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL2105712 AFATINIB DIMALEATE Epidermal growth factor receptor erbB1 inhibitor DailyMed
CHEMBL1201577 CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor DailyMed
CHEMBL1079742 ERLOTINIB HYDROCHLORIDE Epidermal growth factor receptor erbB1 inhibitor DailyMed
CHEMBL939 GEFITINIB Epidermal growth factor receptor erbB1 inhibitor DailyMed
CHEMBL1201179 LAPATINIB DITOSYLATE Epidermal growth factor receptor erbB1 inhibitor DailyMed
CHEMBL1201827 PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000146648
Ensembl ENSG00000146648
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005615 (extracellular space)
GO:0005768 (endosome)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016021 (integral to membrane)
GO:0016323 (basolateral plasma membrane)
GO:0031965 (nuclear membrane)
GO:0070435 (Shc-EGFR complex)
GO Molecular Function GO:0003690 (double-stranded DNA binding)
GO:0004710 (MAP/ERK kinase kinase activity)
GO:0004716 (receptor signaling protein tyrosine kinase activity)
GO:0005006 (epidermal growth factor receptor activity)
GO:0005524 (ATP binding)
GO:0019903 (protein phosphatase binding)
GO:0042802 (identical protein binding)
GO:0046982 (protein heterodimerization activity)
GO:0051015 (actin filament binding)
GO Biological Process GO:0001503 (ossification)
GO:0006950 (response to stress)
GO:0007202 (activation of phospholipase C activity)
GO:0007411 (axon guidance)
GO:0008283 (cell proliferation)
GO:0016337 (cell-cell adhesion)
GO:0030335 (positive regulation of cell migration)
GO:0031659 (positive regulation of cyclin-dependent protein kinase activity involved in G1/S)
GO:0035413 (positive regulation of catenin import into nucleus)
GO:0042059 (negative regulation of epidermal growth factor receptor signaling pathway)
GO:0042327 (positive regulation of phosphorylation)
GO:0043006 (activation of phospholipase A2 activity by calcium-mediated signaling)
GO:0043066 (negative regulation of apoptosis)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0046777 (protein autophosphorylation)
GO:0050679 (positive regulation of epithelial cell proliferation)
GO:0050730 (regulation of peptidyl-tyrosine phosphorylation)
GO:0050999 (regulation of nitric-oxide synthase activity)
GO:0051205 (protein insertion into membrane)
GO:0051897 (positive regulation of protein kinase B signaling cascade)
GO:0070141 (response to UV-A)
Wikipedia Epidermal_growth_factor_receptor

Target Cross References - Protein

canSAR P00533
CGD Acute myeloid leukemia, familial; Lung cancer, familial, susceptibilty to
Human Protein Atlas ENSG00000146648
IntAct P00533
MICAD NBK23179 (Epidermal growth factor receptor)
NBK23211 (Epidermal growth factor receptor)
NBK23370 (Epidermal growth factor receptor (EGFR, HER1/erbB-1))
NBK23376 (Epidermal growth factor receptor (EGFR))
PharmGKB PA7360
Reactome REACT_18266 (Axon guidance.)
REACT_9417 (Signaling by EGFR.)
UniProt O00688 O00732 P00533 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5

Target Cross References - Domain

InterPro IPR000494 (EGF_rcpt_L.)
IPR000719 (Prot_kinase_cat_dom.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR006211 (Furin-like_Cys-rich_dom.)
IPR006212 (Furin_repeat.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR009030 (Growth_fac_rcpt.)
IPR011009 (Kinase-like_dom.)
IPR016245 (Tyr_kinase_EGF/ERB/XmrK_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
Pfam PF00757 (Furin-like)
PF01030 (Recep_L_domain)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1IVO 1M14 1M17 1MOX 1NQL 1XKK 1YY9 2EB2 2EB3 2GS2 2GS6 2GS7 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY 2ITZ 2J5E More...
CREDO 1IVO 1M14 1M17 1MOX 1NQL 1XKK 1YY9 2EB2 2EB3 2GS2 2GS6 2GS7 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY 2ITZ 2J5E More...
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