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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2024
Target Type SINGLE PROTEIN
Preferred Name Follicle stimulating hormone receptor
Synonyms FSH-R | FSHR | Follicle-stimulating hormone receptor | Follitropin receptor | LGR1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > glycohormone receptor > glycohormone receptor

Target Components

Component Description Relationship Accession
Follicle-stimulating hormone receptor SINGLE PROTEIN P23945

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1201692 HUMAN FSH Follicle stimulating hormone receptor agonist DailyMed DailyMed PubMed
CHEMBL2108427 MENOTROPINS Follicle stimulating hormone receptor agonist DailyMed PubMed
CHEMBL1201520 UROFOLLITROPIN Follicle stimulating hormone receptor agonist DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000170820
Ensembl ENSG00000170820
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016021 (integral to membrane)
GO Molecular Function GO:0004963 (follicle-stimulating hormone receptor activity)
GO:0005515 (protein binding)
GO Biological Process GO:0007283 (spermatogenesis)
GO:0007292 (female gamete generation)
GO:0008584 (male gonad development)
Wikipedia Follicle-stimulating_hormone_receptor

Target Cross References - Protein

CGD Ovarian hyperstimulation syndrome; Ovarian dysgenesis 1
Human Protein Atlas ENSG00000170820
IntAct P23945
Guide to Pharmacology 253 (FSH)
PharmGKB PA28386
Reactome REACT_14797 (Signaling by GPCR.)
UniProt A8K947 P23945 Q16225 Q4QRJ3 Q4ZFZ2 Q53RW2

Target Cross References - Domain

InterPro IPR000276 (7TM_GPCR_Rhodpsn.)
IPR000372 (LRR-contain_N.)
IPR001611 (Leu-rich_rpt.)
IPR002131 (Gphrmn_rcpt.)
IPR002272 (FSH_rcpt.)
IPR017452 (GPCR_Rhodpsn_supfam.)
Pfam PF00001 (7tm_1)
PF00560 (LRR_1)
PF01462 (LRRNT)

Target Cross References - Structure

PDBe 1XWD
CREDO 1XWD
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