ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL2009
Preferred Name Glutamate receptor ionotropic, AMPA 1
Synonyms AMPA-selective glutamate receptor 1 | GLUH1 | GLUR1 | GRIA1 | GluA1 | GluR-1 | GluR-A | GluR-K1 | Glutamate receptor 1 | Glutamate receptor ionotropic, AMPA 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > ampa receptor

Target Components

Component Description Relationship Accession
Glutamate receptor 1 SINGLE PROTEIN P42261

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3883294 Glutamate receptor AMPA 1/2 PROTEIN COMPLEX
CHEMBL2096670 Glutamate receptor ionotropic AMPA PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000155511
Ensembl ENSG00000155511
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005768 (endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0008021 (synaptic vesicle)
GO:0008328 (ionotropic glutamate receptor complex)
GO:0009986 (cell surface)
GO:0012507 (ER to Golgi transport vesicle membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0030666 (endocytic vesicle membrane)
GO:0031901 (early endosome membrane)
GO:0032281 (AMPA glutamate receptor complex)
GO:0032590 (dendrite membrane)
GO:0032591 (dendritic spine membrane)
GO:0033116 (endoplasmic reticulum-Golgi intermediate compartment membrane)
GO:0036477 (somatodendritic compartment)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043197 (dendritic spine)
GO:0044308 (axonal spine)
GO:0044309 (neuron spine)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0055037 (recycling endosome)
GO:0055038 (recycling endosome membrane)
GO:0098794 (postsynapse)
GO:0098839 (postsynaptic density membrane)
GO Molecular Function GO:0001540 (beta-amyloid binding)
GO:0004970 (ionotropic glutamate receptor activity)
GO:0004971 (AMPA glutamate receptor activity)
GO:0005216 (ion channel activity)
GO:0005231 (excitatory extracellular ligand-gated ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0005515 (protein binding)
GO:0008066 (glutamate receptor activity)
GO:0030165 (PDZ domain binding)
GO:0038023 (signaling receptor activity)
GO:0099583 (neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)
GO:1904315 (transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)
GO Biological Process GO:0006811 (ion transport)
GO:0006888 (ER to Golgi vesicle-mediated transport)
GO:0007165 (signal transduction)
GO:0007268 (chemical synaptic transmission)
GO:0007616 (long-term memory)
GO:0031623 (receptor internalization)
GO:0034220 (ion transmembrane transport)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0048208 (COPII vesicle coating)
GO:0060078 (regulation of postsynaptic membrane potential)
GO:0060079 (excitatory postsynaptic potential)
GO:0060292 (long term synaptic depression)
GO:0099566 (regulation of postsynaptic cytosolic calcium ion concentration)
Wikipedia GRIA1

Target Cross References - Protein

canSAR P42261
Human Protein Atlas ENSG00000155511
IntAct P42261
Guide to Pharmacology 444
Open Targets ENSG00000155511
PharmGKB PA28966
Pharos P42261 (Tclin)
Reactome R-HSA-204005 (COPII (Coat Protein 2) Mediated Vesicle Transport.)
R-HSA-399710 (Activation of AMPA receptors.)
R-HSA-399719 (Trafficking of AMPA receptors.)
R-HSA-416993 (Trafficking of GluR2-containing AMPA receptors.)
R-HSA-438066 (Unblocking of NMDA receptor, glutamate binding and activation.)
R-HSA-5694530 (Cargo concentration in the ER.)
R-HSA-8849932 (Synaptic adhesion-like molecules.)
UniProt B7Z2S0 B7Z2W8 B7Z3F6 B7Z9G9 D3DQI4 E7ESV8 P42261 Q2NKM6

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10613 (Lig_chan-Glu_bd)