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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1997
Preferred Name Equilibrative nucleoside transporter 1
Synonyms ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | Equilibrative nucleoside transporter 1 | Nucleoside transporter, es-type | SLC29A1 | Solute carrier family 29 member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc28 and slc29 families of nucleoside transporters > slc29 facilitative nucleoside transporter family

Target Components

Component Description Relationship Accession
Equilibrative nucleoside transporter 1 SINGLE PROTEIN Q99808

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL932 DIPYRIDAMOLE Equilibrative nucleoside transporter 1 inhibitor 4 DailyMed UniProt

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000112759
Ensembl ENSG00000112759
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO:0098794 (postsynapse)
GO Molecular Function GO:0005337 (nucleoside transmembrane transporter activity)
GO Biological Process GO:0006139 (nucleobase-containing compound metabolic process)
GO:0007595 (lactation)
GO:0015858 (nucleoside transport)
GO:0015862 (uridine transport)
GO:0030431 (sleep)
GO:0060079 (excitatory postsynaptic potential)
GO:0071333 (cellular response to glucose stimulus)
GO:0071456 (cellular response to hypoxia)
GO:1901642 (nucleoside transmembrane transport)
Wikipedia Equilibrative_nucleoside_transporter_1

Target Cross References - Protein

canSAR Q99808
Human Protein Atlas ENSG00000112759
IntAct Q99808
Guide to Pharmacology 1117
Open Targets ENSG00000112759
PharmGKB PA154
Reactome R-HSA-83936 (Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.)
UniProt B3KQV7 B3KQY5 Q5T9W9 Q99808 Q9UJY2

Target Cross References - Domain

InterPro IPR002259 (Eqnu_transpt.)
IPR030195 (ENT1.)
IPR034764 (ENT1/ENT2.)
IPR036259 (MFS_trans_sf.)
Pfam PF01733 (Nucleoside_tran)