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Target Report Card

Target Name and Classification

Target ID CHEMBL1991
Preferred Name Inhibitor of nuclear factor kappa B kinase beta subunit
Synonyms I-kappa-B kinase 2 | I-kappa-B-kinase beta | IKBKB | IKK-B | IKK-beta | IKK2 | IKKB | IkBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | NFKBIKB | Nuclear factor NF-kappa-B inhibitor kinase beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group

Target Components

Component Description Relationship Accession
Inhibitor of nuclear factor kappa-B kinase subunit beta SINGLE PROTEIN O14920

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3883298 Inhibitor of NF-kappa-B kinase alpha/beta PROTEIN COMPLEX
CHEMBL2111328 Inhibitor of NF-kappa-B kinase (IKK) PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1762621 BARDOXOLONE METHYL Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor 3 PubMed PubMed
CHEMBL3544945 SAR-113945 Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor 2 Other
CHEMBL3545168 IMD-1041 Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor 2 Other PubMed
CHEMBL129857 AS-602868 Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor 1 PubMed PubMed
CHEMBL3545089 IMD-0354 Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor 1 PubMed
CHEMBL3545147 IMD-2560 Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor 1 Other PubMed
CHEMBL3545265 MLN-0415 Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor 1 Other Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000104365
Ensembl ENSG00000104365
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0008385 (IkappaB kinase complex)
GO:0009898 (cytoplasmic side of plasma membrane)
GO:0016020 (membrane)
GO:0035631 (CD40 receptor complex)
GO:0045121 (membrane raft)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008384 (IkappaB kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0002479 (antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)
GO:0002756 (MyD88-independent toll-like receptor signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0006954 (inflammatory response)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0007252 (I-kappaB phosphorylation)
GO:0009615 (response to virus)
GO:0009653 (anatomical structure morphogenesis)
GO:0010803 (regulation of tumor necrosis factor-mediated signaling pathway)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0030866 (cortical actin cytoskeleton organization)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0035509 (negative regulation of myosin-light-chain-phosphatase activity)
GO:0035666 (TRIF-dependent toll-like receptor signaling pathway)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0042325 (regulation of phosphorylation)
GO:0043066 (negative regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0045087 (innate immune response)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050852 (T cell receptor signaling pathway)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051403 (stress-activated MAPK cascade)
GO:0070423 (nucleotide-binding oligomerization domain containing signaling pathway)
GO:0070498 (interleukin-1-mediated signaling pathway)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0072659 (protein localization to plasma membrane)
GO:1903140 (regulation of establishment of endothelial barrier)
GO:1903347 (negative regulation of bicellular tight junction assembly)
Wikipedia IKK2

Target Cross References - Protein

canSAR O14920
Human Protein Atlas ENSG00000104365
IntAct O14920
Guide to Pharmacology 2039
Open Targets ENSG00000104365
PharmGKB PA29776
Pharos O14920 (Tchem)
Reactome R-HSA-1169091 (Activation of NF-kappaB in B cells.)
R-HSA-1236974 (ER-Phagosome pathway.)
R-HSA-168638 (NOD1/2 Signaling Pathway.)
R-HSA-168927 (TICAM1, RIP1-mediated IKK complex recruitment.)
R-HSA-1810476 (RIP-mediated NFkB activation via ZBP1.)
R-HSA-202424 (Downstream TCR signaling.)
R-HSA-209543 (p75NTR recruits signalling complexes.)
R-HSA-209560 (NF-kB is activated and signals survival.)
R-HSA-2871837 (FCERI mediated NF-kB activation.)
R-HSA-445989 (TAK1 activates NFkB by phosphorylation and activation of IKKs complex.)
R-HSA-5357905 (Regulation of TNFR1 signaling.)
R-HSA-5357956 (TNFR1-induced NFkappaB signaling pathway.)
R-HSA-5602636 (IKBKB deficiency causes SCID.)
R-HSA-5603027 (IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR).)
R-HSA-5603029 (IkBA variant leads to EDA-ID.)
R-HSA-5607764 (CLEC7A (Dectin-1) signaling.)
R-HSA-5684264 (MAP3K8 (TPL2)-dependent MAPK1/3 activation.)
R-HSA-9020702 (Interleukin-1 signaling.)
R-HSA-933542 (TRAF6 mediated NF-kB activation.)
R-HSA-933543 (NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10.)
R-HSA-937039 (IRAK1 recruits IKK complex.)
R-HSA-937041 (IKK complex recruitment mediated by RIP1.)
R-HSA-975144 (IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.)
UniProt B4DZ30 B4E0U4 O14920 O75327

Target Cross References - Domain

InterPro IPR000626 (Ubiquitin_dom.)
IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR022007 (IKKbetaNEMObind.)
IPR029071 (Ubiquitin-like_domsf.)
Pfam PF00069 (Pkinase)
PF12179 (IKKbetaNEMObind)

Target Cross References - Structure