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Target Report Card

Target Name and Classification

Target ID CHEMBL1988
Preferred Name Atrial natriuretic peptide receptor A
Synonyms ANP-A | ANPR-A | ANPRA | Atrial natriuretic peptide receptor 1 | Atrial natriuretic peptide receptor type A | GC-A | Guanylate cyclase A | NPR-A | NPR1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > lyase > guanylate cyclase > receptor guanylate cyclase

Target Components

Component Description Relationship Accession
Atrial natriuretic peptide receptor 1 SINGLE PROTEIN P16066

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111337 Atrial natriuretic peptide receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201668 NESIRITIDE Atrial natriuretic peptide receptor A agonist 4 DailyMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000169418
Ensembl ENSG00000169418
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0008074 (guanylate cyclase complex, soluble)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004016 (adenylate cyclase activity)
GO:0004383 (guanylate cyclase activity)
GO:0004672 (protein kinase activity)
GO:0005524 (ATP binding)
GO:0005525 (GTP binding)
GO:0008528 (G-protein coupled peptide receptor activity)
GO:0016829 (lyase activity)
GO:0016849 (phosphorus-oxygen lyase activity)
GO:0016941 (natriuretic peptide receptor activity)
GO:0017046 (peptide hormone binding)
GO:0019901 (protein kinase binding)
GO:0042562 (hormone binding)
GO Biological Process GO:0006182 (cGMP biosynthetic process)
GO:0006468 (protein phosphorylation)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007168 (receptor guanylyl cyclase signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007589 (body fluid secretion)
GO:0008217 (regulation of blood pressure)
GO:0009190 (cyclic nucleotide biosynthetic process)
GO:0016525 (negative regulation of angiogenesis)
GO:0030308 (negative regulation of cell growth)
GO:0030828 (positive regulation of cGMP biosynthetic process)
GO:0035556 (intracellular signal transduction)
GO:0035810 (positive regulation of urine volume)
GO:0035815 (positive regulation of renal sodium excretion)
GO:0042312 (regulation of vasodilation)
GO:0042417 (dopamine metabolic process)
GO:0043114 (regulation of vascular permeability)
GO:0048662 (negative regulation of smooth muscle cell proliferation)
GO:0050880 (regulation of blood vessel size)
GO:1903779 (regulation of cardiac conduction)
Wikipedia NPR1

Target Cross References - Protein

canSAR P16066
Human Protein Atlas ENSG00000169418
IntAct P16066
Guide to Pharmacology 1747
Open Targets ENSG00000169418
PharmGKB PA31736
Pharos P16066 (Tclin)
Reactome R-HSA-5578768 (Physiological factors.)
UniProt B0ZBF0 P16066 Q5SR08 Q6P4Q3

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001054 (A/G_cyclase.)
IPR001170 (ANPR/GUC.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR011009 (Kinase-like_dom.)
IPR018297 (A/G_cyclase_CS.)
IPR028082 (Peripla_BP_I.)
IPR029787 (Nucleotide_cyclase.)
Pfam PF00211 (Guanylate_cyc)
PF01094 (ANF_receptor)
PF07714 (Pkinase_Tyr)