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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1983
Target Type SINGLE PROTEIN
Preferred Name Serotonin 1d (5-HT1d) receptor
Synonyms 5-HT-1D | 5-HT-1D-alpha | 5-HT1D | 5-hydroxytryptamine receptor 1D | HTR1D | HTR1DA | HTRL | Serotonin 1D alpha receptor | Serotonin receptor 1D
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > serotonin receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 1D SINGLE PROTEIN P28221

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095230 Serotonin 1 receptors; 5-HT1B & 5-HT1D SELECTIVITY GROUP
CHEMBL2096904 Serotonin (5-HT) receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL128 SUMATRIPTAN Serotonin 1d (5-HT1d) receptor agonist 4 FDA
CHEMBL1185 ZOLMITRIPTAN Serotonin 1d (5-HT1d) receptor agonist 4 FDA
CHEMBL1200371 FROVATRIPTAN SUCCINATE Serotonin 1d (5-HT1d) receptor agonist 4 FDA
CHEMBL1200517 DIHYDROERGOTAMINE MESYLATE Serotonin 1d (5-HT1d) receptor agonist 4 DailyMed
CHEMBL1200521 ALMOTRIPTAN MALATE Serotonin 1d (5-HT1d) receptor agonist 4 FDA
CHEMBL1200601 NARATRIPTAN HYDROCHLORIDE Serotonin 1d (5-HT1d) receptor agonist 4 FDA
CHEMBL1201003 ELETRIPTAN HYDROBROMIDE Serotonin 1d (5-HT1d) receptor agonist 4 FDA
CHEMBL1201032 RIZATRIPTAN BENZOATE Serotonin 1d (5-HT1d) receptor agonist 4 FDA
CHEMBL1201150 SUMATRIPTAN SUCCINATE Serotonin 1d (5-HT1d) receptor agonist 4 FDA
CHEMBL2062265 ERGOTAMINE TARTRATE Serotonin 1d (5-HT1d) receptor agonist 4 DailyMed ISBN PubMed
CHEMBL1631540 GSK163090 Serotonin 1d (5-HT1d) receptor antagonist 2 PubMed
CHEMBL1742428 DONITRIPTAN Serotonin 1d (5-HT1d) receptor agonist 2 PubMed
CHEMBL2106698 ELZASONAN HYDROCHLORIDE Serotonin 1d (5-HT1d) receptor antagonist 2 PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000179546
Ensembl ENSG00000179546
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004993 (G-protein coupled serotonin receptor activity)
GO:0051378 (serotonin binding)
GO Biological Process GO:0006939 (smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007210 (serotonin receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0009636 (response to toxic substance)
GO:0014827 (intestine smooth muscle contraction)
GO:0040012 (regulation of locomotion)
GO:0042310 (vasoconstriction)
GO:0050795 (regulation of behavior)
Wikipedia 5-HT1D_receptor

Target Cross References - Protein

canSAR P28221
Human Protein Atlas ENSG00000179546
Guide to Pharmacology 3
Open Targets ENSG00000179546
PharmGKB PA29550
Pharos P28221 (Tclin)
Reactome R-HSA-390666 (Serotonin receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt P28221

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000505 (5HT1D_rcpt.)
IPR002231 (5HT_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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