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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL1981
Target Type SINGLE PROTEIN
Preferred Name Insulin receptor
Synonyms Object
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase insr family

Target Components

Component Description Relationship Accession
Insulin receptor SINGLE PROTEIN P06213

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171105
Ensembl ENSG00000171105
GO Cellular Component GO:0005887 (integral component of plasma membrane)
GO:0005899 (insulin receptor complex)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0016020 (membrane)
GO:0043235 (receptor complex)
GO:0070062 (extracellular exosome)
GO:0005901 (caveola)
GO:0005886 (plasma membrane)
GO:0010008 (endosome membrane)
GO Molecular Function GO:0004716 (receptor signaling protein tyrosine kinase activity)
GO:0043560 (insulin receptor substrate binding)
GO:0005525 (GTP binding)
GO:0031995 (insulin-like growth factor II binding)
GO:0043559 (insulin binding)
GO:0005009 (insulin-activated receptor activity)
GO:0005524 (ATP binding)
GO:0043548 (phosphatidylinositol 3-kinase binding)
GO:0051425 (PTB domain binding)
GO:0004713 (protein tyrosine kinase activity)
GO:0005159 (insulin-like growth factor receptor binding)
GO:0031994 (insulin-like growth factor I binding)
GO Biological Process GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0071363 (cellular response to growth factor stimulus)
GO:0042593 (glucose homeostasis)
GO:0045740 (positive regulation of DNA replication)
GO:0046326 (positive regulation of glucose import)
GO:0003007 (heart morphogenesis)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0008286 (insulin receptor signaling pathway)
GO:0019087 (transformation of host cell by virus)
GO:0030325 (adrenal gland development)
GO:0031017 (exocrine pancreas development)
GO:0046777 (protein autophosphorylation)
GO:0030335 (positive regulation of cell migration)
GO:0008284 (positive regulation of cell proliferation)
GO:0032147 (activation of protein kinase activity)
GO:0032148 (activation of protein kinase B activity)
GO:0043410 (positive regulation of MAPK cascade)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0051446 (positive regulation of meiotic cell cycle)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0008544 (epidermis development)
GO:0008584 (male gonad development)
GO:0032869 (cellular response to insulin stimulus)
GO:0045821 (positive regulation of glycolytic process)
GO:0051290 (protein heterotetramerization)
GO:0000187 (activation of MAPK activity)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0005975 (carbohydrate metabolic process)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0045840 (positive regulation of mitotic nuclear division)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045995 (regulation of embryonic development)
GO:0048639 (positive regulation of developmental growth)
GO:0030238 (male sex determination)
GO:0045725 (positive regulation of glycogen biosynthetic process)
GO:0060267 (positive regulation of respiratory burst)
GO:2000194 (regulation of female gonad development)
Wikipedia Insulin_receptor

Target Cross References - Protein

CGD Hyperinsulinemic hypoglycemia, familial, 5; Rabson-Mendenhall syndrome; Donohoe syndrome
Human Protein Atlas ENSG00000171105
IntAct P06213
Guide to Pharmacology 1800 (Insulin receptor)
PharmGKB PA202
UniProt Q59H98 Q9UCB7 Q9UCB9 Q9UCB8 P06213 Q17RW0

Target Cross References - Domain

InterPro IPR000494 (Rcpt_L-dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR009030 (Growth_fac_rcpt_N_dom.)
IPR016246 (Tyr_kinase_insulin-like_rcpt.)
IPR003961 (FN3_dom.)
IPR006212 (Furin_repeat.)
IPR000719 (Prot_kinase_dom.)
IPR002011 (Tyr_kinase_rcpt_2_CS.)
IPR006211 (Furin-like_Cys-rich_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR013783 (Ig-like_fold.)
IPR011009 (Kinase-like_dom.)
Pfam PF00041 (fn3)
PF01030 (Recep_L_domain)
PF07714 (Pkinase_Tyr)
PF00757 (Furin-like)

Target Cross References - Structure

PDBe 2B4S 3W13 3W14 4XLV 1IRK 3EKK 1GAG 1IR3 5E1S 1P14 3BU5 3BU6 3ETA 3LOH 3W12 3W11 4OGA 1I44 2AUH 4XST 2DTG 2HR7 3BU3 3EKN More...
CREDO 2B4S 3W13 3W14 4XLV 1IRK 3EKK 1GAG 1IR3 5E1S 1P14 3BU5 3BU6 3ETA 3LOH 3W12 3W11 4OGA 1I44 2AUH 4XST 2DTG 2HR7 3BU3 3EKN More...
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