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Target Report Card

Target Name and Classification

Target ID CHEMBL1971
Preferred Name Sulfonylurea receptor 2
Synonyms ABCC9 | ATP-binding cassette sub-family C member 9 | SUR2 | Sulfonylurea receptor 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > atp-binding cassette > abcc subfamily

Target Components

Component Description Relationship Accession
ATP-binding cassette sub-family C member 9 SINGLE PROTEIN O60706

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095152 Sulfonylurea receptors; K-ATP channels PROTEIN COMPLEX GROUP
CHEMBL2095198 Sulfonylurea receptor 2, Kir6.2 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000069431
Ensembl ENSG00000069431
GO Cellular Component GO:0005886 (plasma membrane)
GO:0008282 (ATP-sensitive potassium channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030017 (sarcomere)
GO:0042383 (sarcolemma)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005215 (transporter activity)
GO:0005267 (potassium channel activity)
GO:0005524 (ATP binding)
GO:0008281 (sulfonylurea receptor activity)
GO:0015459 (potassium channel regulator activity)
GO:0016887 (ATPase activity)
GO:0042626 (ATPase activity, coupled to transmembrane movement of substances)
GO:0043225 (anion transmembrane-transporting ATPase activity)
GO:0044325 (ion channel binding)
GO Biological Process GO:0006813 (potassium ion transport)
GO:0007165 (signal transduction)
GO:0010107 (potassium ion import)
GO:0042493 (response to drug)
GO:0051607 (defense response to virus)
GO:0055085 (transmembrane transport)
GO:0099133 (ATP hydrolysis coupled anion transmembrane transport)
GO:1903779 (regulation of cardiac conduction)
Wikipedia ABCC9

Target Cross References - Protein

canSAR O60706
CGD Cardiomyopathy, dilated, 10; Atrial fibrillation, familial 12; Cantu syndrome
Human Protein Atlas ENSG00000069431
IntAct O60706
Guide to Pharmacology 2746
Open Targets ENSG00000069431
PharmGKB PA396
Reactome R-HSA-1296025 (ATP sensitive Potassium channels.)
R-HSA-382556 (ABC-family proteins mediated transport.)
R-HSA-5578775 (Ion homeostasis.)
R-HSA-5678420 (Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia.)
UniProt O60706 O60707

Target Cross References - Domain

InterPro IPR000388 (Sulphorea_rcpt.)
IPR001475 (ABCC9.)
IPR003439 (ABC_transporter-like.)
IPR003593 (AAA+_ATPase.)
IPR011527 (ABC1_TM_dom.)
IPR017871 (ABC_transporter_CS.)
IPR027417 (P-loop_NTPase.)
IPR036640 (ABC1_TM_sf.)
Pfam PF00005 (ABC_tran)
PF00664 (ABC_membrane)