ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1970
Target Type SINGLE PROTEIN
Preferred Name Alcohol dehydrogenase alpha chain
Synonyms ADH1 | ADH1A | Alcohol dehydrogenase 1A | Alcohol dehydrogenase subunit alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Alcohol dehydrogenase 1A SINGLE PROTEIN P07327

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096668 Alcohol dehydrogenase PROTEIN FAMILY
CHEMBL2363044 Alcohol dehydrogenase class I PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000187758
Ensembl ENSG00000187758
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004022 (alcohol dehydrogenase (NAD) activity)
GO:0004024 (alcohol dehydrogenase activity, zinc-dependent)
GO:0004745 (retinol dehydrogenase activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016491 (oxidoreductase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006066 (alcohol metabolic process)
GO:0006069 (ethanol oxidation)
GO:0017144 (drug metabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia ADH1A

Target Cross References - Protein

canSAR P07327
Human Protein Atlas ENSG00000187758
IntAct P07327
Open Targets ENSG00000187758
PharmGKB PA24570
Reactome R-HSA-2161541 (Abacavir metabolism.)
R-HSA-5365859 (RA biosynthesis pathway.)
R-HSA-71384 (Ethanol oxidation.)
UniProt A8K3E3 P07327 Q17R68

Target Cross References - Domain

InterPro IPR002328 (ADH_Zn_CS.)
IPR011032 (GroES-like.)
IPR013149 (ADH_C.)
IPR013154 (ADH_N.)
IPR016040 (NAD(P)-bd_dom.)
IPR020843 (PKS_ER.)
Pfam PF00107 (ADH_zinc_N)
PF08240 (ADH_N)

Target Cross References - Structure

PDBe 1HSO 1U3T
CREDO 1HSO 1U3T
spacer
spacer