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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1958
Preferred Name 3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
Synonyms 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I | 3-beta-HSD I | 3-beta-hydroxy-5-ene steroid dehydrogenase | 3-beta-hydroxy-Delta(5)-steroid dehydrogenase | 3BH | Delta-5-3-ketosteroid isomerase | HSD3B1 | HSDB3A | Progesterone reductase | Steroid Delta-isomerase | Trophoblast antigen FDO161G
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 SINGLE PROTEIN P14060

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000203857
Ensembl ENSG00000203857
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0005758 (mitochondrial intermembrane space)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030868 (smooth endoplasmic reticulum membrane)
GO:0031966 (mitochondrial membrane)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0003854 (3-beta-hydroxy-delta5-steroid dehydrogenase activity)
GO:0004769 (steroid delta-isomerase activity)
GO:0016491 (oxidoreductase activity)
GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
GO:0016853 (isomerase activity)
GO:0102294 (cholesterol dehydrogenase activity)
GO Biological Process GO:0006694 (steroid biosynthetic process)
GO:0006702 (androgen biosynthetic process)
GO:0006703 (estrogen biosynthetic process)
GO:0006704 (glucocorticoid biosynthetic process)
GO:0006705 (mineralocorticoid biosynthetic process)
GO:0008152 (metabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia HSD3B1

Target Cross References - Protein

canSAR P14060
Human Protein Atlas ENSG00000203857
Open Targets ENSG00000203857
PharmGKB PA29486
Reactome R-HSA-193048 (Androgen biosynthesis.)
R-HSA-193993 (Mineralocorticoid biosynthesis.)
R-HSA-194002 (Glucocorticoid biosynthesis.)
UniProt A8K691 P14060 Q14545 Q8IV65

Target Cross References - Domain

InterPro IPR002225 (3Beta_OHSteriod_DH/Estase.)
IPR036291 (NAD(P)-bd_dom_sf.)
Pfam PF01073 (3Beta_HSD)