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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1955
Target Type SINGLE PROTEIN
Preferred Name Vascular endothelial growth factor receptor 3
Synonyms FLT-4 | FLT4 | Fms-like tyrosine kinase 4 | Tyrosine-protein kinase receptor FLT4 | VEGFR-3 | VEGFR3 | Vascular endothelial growth factor receptor 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase vegfr family

Target Components

Component Description Relationship Accession
Vascular endothelial growth factor receptor 3 SINGLE PROTEIN P35916

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3301389 Focal adhesion kinase 1/vascular endothelial growth factor receptor 3 PROTEIN-PROTEIN INTERACTION
CHEMBL2111409 Vascular endothelial growth factor receptor 2 and 3 (KDR and Flt-4) SELECTIVITY GROUP
CHEMBL2095227 Vascular endothelial growth factor receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545026 FAMITINIB Vascular endothelial growth factor receptor 3 inhibitor 3 DOI PubMed
CHEMBL2079588 TELATINIB Vascular endothelial growth factor receptor 3 inhibitor 2 PubMed PubMed
CHEMBL3545021 ANLOTINIB Vascular endothelial growth factor receptor 3 inhibitor 2 ClinicalTrials Other
CHEMBL2109602 IMC-3C5 Vascular endothelial growth factor receptor 3 inhibitor 1 Other PubMed
CHEMBL3545133 JNJ-26483327 Vascular endothelial growth factor receptor 3 inhibitor 1 DOI PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000037280
Ensembl ENSG00000037280
GO Cellular Component GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005021 (vascular endothelial growth factor-activated receptor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019838 (growth factor binding)
GO:0019903 (protein phosphatase binding)
GO:0036328 (VEGF-C-activated receptor activity)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0001944 (vasculature development)
GO:0001945 (lymph vessel development)
GO:0001946 (lymphangiogenesis)
GO:0002040 (sprouting angiogenesis)
GO:0003016 (respiratory system process)
GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007585 (respiratory gaseous exchange)
GO:0008284 (positive regulation of cell proliferation)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0010595 (positive regulation of endothelial cell migration)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
GO:0038084 (vascular endothelial growth factor signaling pathway)
GO:0043066 (negative regulation of apoptotic process)
GO:0043410 (positive regulation of MAPK cascade)
GO:0046330 (positive regulation of JNK cascade)
GO:0046777 (protein autophosphorylation)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048286 (lung alveolus development)
GO:0048514 (blood vessel morphogenesis)
GO:0060312 (regulation of blood vessel remodeling)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0090037 (positive regulation of protein kinase C signaling)
Wikipedia FLT4

Target Cross References - Protein

CGD Lymphedema, hereditary I (Milory disease)
Human Protein Atlas ENSG00000037280
IntAct P35916
Guide to Pharmacology 1814
Open Targets ENSG00000037280
PharmGKB PA28183
Pharos P35916 (Tclin)
Reactome R-HSA-195399 (VEGF binds to VEGFR leading to receptor dimerization.)
UniProt A8K6L4 B5A926 P35916 Q16067 Q86W07 Q86W08

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001824 (Tyr_kinase_rcpt_3_CS.)
IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR009137 (VEGFR3_rcpt.)
IPR011009 (Kinase-like_dom_sf.)
IPR013098 (Ig_I-set.)
IPR013783 (Ig-like_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR036179 (Ig-like_dom_sf.)
Pfam PF07679 (I-set)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 4BSJ 4BSK
CREDO 4BSJ 4BSK
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