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Target Report Card

Target Name and Classification

Target ID CHEMBL1952
Preferred Name Thymidylate synthase
Synonyms TS | TSase | TYMS | Thymidylate synthase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > transferase

Target Components

Component Description Relationship Accession
Thymidylate synthase SINGLE PROTEIN P04818

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885528 Thymidylate synthase/GAR transformylase/AICAR transformylase PROTEIN FAMILY
CHEMBL3885527 Thymidylate synthase/AICAR transformylase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL917 FLOXURIDINE Thymidylate synthase inhibitor 4 PubMed PubMed PubMed PubMed
CHEMBL185 FLUOROURACIL Thymidylate synthase inhibitor 4 DailyMed
CHEMBL225071 RALTITREXED Thymidylate synthase inhibitor 4 PubMed PubMed
CHEMBL1773 CAPECITABINE Thymidylate synthase inhibitor 4 DailyMed
CHEMBL2360464 PEMETREXED DISODIUM Thymidylate synthase inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000176890
Ensembl ENSG00000176890
GO Cellular Component GO:0005634 (nucleus)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0005759 (mitochondrial matrix)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000900 (translation repressor activity, nucleic acid binding)
GO:0003729 (mRNA binding)
GO:0004799 (thymidylate synthase activity)
GO:0005542 (folic acid binding)
GO:0008144 (drug binding)
GO:0008168 (methyltransferase activity)
GO:0016740 (transferase activity)
GO:0042803 (protein homodimerization activity)
GO:0048037 (cofactor binding)
GO:1990825 (sequence-specific mRNA binding)
GO Biological Process GO:0000083 (regulation of transcription involved in G1/S transition of mitotic cell cycle)
GO:0006206 (pyrimidine nucleobase metabolic process)
GO:0006231 (dTMP biosynthetic process)
GO:0006235 (dTTP biosynthetic process)
GO:0006417 (regulation of translation)
GO:0007568 (aging)
GO:0007623 (circadian rhythm)
GO:0009165 (nucleotide biosynthetic process)
GO:0009636 (response to toxic substance)
GO:0014070 (response to organic cyclic compound)
GO:0015949 (nucleobase-containing small molecule interconversion)
GO:0017148 (negative regulation of translation)
GO:0019088 (immortalization of host cell by virus)
GO:0019860 (uracil metabolic process)
GO:0032259 (methylation)
GO:0032570 (response to progesterone)
GO:0033189 (response to vitamin A)
GO:0034097 (response to cytokine)
GO:0035999 (tetrahydrofolate interconversion)
GO:0042493 (response to drug)
GO:0045471 (response to ethanol)
GO:0046078 (dUMP metabolic process)
GO:0046653 (tetrahydrofolate metabolic process)
GO:0046683 (response to organophosphorus)
GO:0048589 (developmental growth)
GO:0051216 (cartilage development)
GO:0051384 (response to glucocorticoid)
GO:0051593 (response to folic acid)
GO:0060574 (intestinal epithelial cell maturation)
GO:0071897 (DNA biosynthetic process)
GO:0097421 (liver regeneration)
Wikipedia Thymidylate_synthase

Target Cross References - Protein

canSAR P04818
Human Protein Atlas ENSG00000176890
IntAct P04818
Guide to Pharmacology 2642
Open Targets ENSG00000176890
PharmGKB PA359
Reactome R-HSA-499943 (Interconversion of nucleotide di- and triphosphates.)
R-HSA-539107 (Activation of E2F1 target genes at G1/S.)
UniProt P04818 Q8WYK3 Q8WYK4

Target Cross References - Domain

InterPro IPR000398 (Thymidylate_synthase.)
IPR020940 (Thymidylate_synthase_AS.)
IPR023451 (Thymidate_synth/dCMP_Mease.)
IPR036926 (Thymidate_synth/dCMP_Mease_sf.)
Pfam PF00303 (Thymidylat_synt)

Target Cross References - Structure

PDBe 1HVY 1HW3 1HW4 1HZW 1I00 1JU6 1JUJ 1YPV 2ONB 2RD8 2RDA 3EAW 3EBU 3ED7 3EDW 3EF9 3EGY 3EHI 3EJL 3GG5 3GH0 3GH2 3H9K 3HB8 More...
CREDO 1HVY 1HW3 1HW4 1HZW 1I00 1JU6 1JUJ 1YPV 2ONB 2RD8 2RDA 3EAW 3EBU 3ED7 3EDW 3EF9 3EGY 3EHI 3EJL 3GG5 3GH0 3GH2 3H9K 3HB8 More...