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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1951
Target Type SINGLE PROTEIN
Preferred Name Monoamine oxidase A
Synonyms Amine oxidase [flavin-containing] A | MAO-A | MAOA | Monoamine oxidase type A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Amine oxidase [flavin-containing] A SINGLE PROTEIN P21397

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095205 Monoamine oxidase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3707400 Indantadol Monoamine oxidase A inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000189221
Ensembl ENSG00000189221
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0008131 (primary amine oxidase activity)
GO:0016491 (oxidoreductase activity)
GO:0050660 (flavin adenine dinucleotide binding)
GO:0051378 (serotonin binding)
GO Biological Process GO:0006576 (cellular biogenic amine metabolic process)
GO:0006584 (catecholamine metabolic process)
GO:0042133 (neurotransmitter metabolic process)
GO:0042135 (neurotransmitter catabolic process)
GO:0042420 (dopamine catabolic process)
GO:0042428 (serotonin metabolic process)
GO:0042443 (phenylethylamine metabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia Monoamine_oxidase_A

Target Cross References - Protein

canSAR P21397
CGD Brunner syndrome
Human Protein Atlas ENSG00000189221
IntAct P21397
Guide to Pharmacology 2489
MICAD NBK23088 (Monoamine oxidase A (MAO-A))
Open Targets ENSG00000189221
PharmGKB PA236
Reactome R-HSA-141333 (Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB.)
R-HSA-181430 (Norepinephrine Neurotransmitter Release Cycle.)
R-HSA-379397 (Enzymatic degradation of dopamine by COMT.)
R-HSA-379398 (Enzymatic degradation of Dopamine by monoamine oxidase.)
R-HSA-380612 (Metabolism of serotonin.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt B4DF46 P21397 Q16426

Target Cross References - Domain

InterPro IPR001613 (Flavin_amine_oxidase.)
IPR002937 (Amino_oxidase.)
IPR023753 (FAD/NAD-binding_dom.)
Pfam PF01593 (Amino_oxidase)

Target Cross References - Structure

PDBe 2BXR 2BXS 2Z5X 2Z5Y
CREDO 2BXR 2BXS 2Z5X 2Z5Y
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