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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1951
Target Type SINGLE PROTEIN
Preferred Name Monoamine oxidase A
Synonyms Amine oxidase [flavin-containing] A | MAO-A | MAOA | Monoamine oxidase type A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Amine oxidase [flavin-containing] A SINGLE PROTEIN P21397

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095205 Monoamine oxidase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000189221
Ensembl ENSG00000189221
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0050660 (flavin adenine dinucleotide binding)
GO:0051378 (serotonin binding)
GO:0008131 (primary amine oxidase activity)
GO Biological Process GO:0042135 (neurotransmitter catabolic process)
GO:0044281 (small molecule metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0042136 (neurotransmitter biosynthetic process)
GO:0007268 (synaptic transmission)
GO:0007269 (neurotransmitter secretion)
GO:0006576 (cellular biogenic amine metabolic process)
GO:0042420 (dopamine catabolic process)
GO:0042428 (serotonin metabolic process)
GO:0042443 (phenylethylamine metabolic process)
Wikipedia Monoamine_oxidase_A

Target Cross References - Protein

canSAR P21397
CGD Brunner syndrome
Human Protein Atlas ENSG00000189221
IntAct P21397
Guide to Pharmacology 2489 (Monoamine oxidase A)
MICAD NBK23088 (Monoamine oxidase A (MAO-A))
PharmGKB PA236
UniProt P21397 Q16426

Target Cross References - Domain

InterPro IPR001613 (Flavin_amine_oxidase.)
IPR002937 (Amino_oxidase.)
IPR023753 (FAD/NAD-binding_dom.)
Pfam PF01593 (Amino_oxidase)

Target Cross References - Structure

PDBe 2BXS 2Z5X 2Z5Y 2BXR
CREDO 2BXS 2Z5X 2Z5Y 2BXR
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