ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL1946
Preferred Name Melatonin receptor 1B
Synonyms MTNR1B | Mel-1B-R | Mel1b receptor | Melatonin receptor type 1B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine-derivative receptor (family a gpcr) > melatonin receptor

Target Components

Component Description Relationship Accession
Melatonin receptor type 1B SINGLE PROTEIN P49286

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094268 Melatonin receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134640
Ensembl ENSG00000134640
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0008502 (melatonin receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007268 (chemical synaptic transmission)
GO:0007623 (circadian rhythm)
GO:0042593 (glucose homeostasis)
GO:0050796 (regulation of insulin secretion)
Wikipedia Melatonin_receptor_1B

Target Cross References - Protein

canSAR P49286
Human Protein Atlas ENSG00000134640
IntAct P49286
Guide to Pharmacology 288
Open Targets ENSG00000134640
PharmGKB PA31268
Pharos P49286 (Tclin)
Reactome R-HSA-373076 (Class A/1 (Rhodopsin-like receptors).)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt P49286

Target Cross References - Domain

InterPro IPR000025 (Melatonin_rcpt.)
IPR000276 (GPCR_Rhodpsn.)
IPR002278 (Mel_1A/1B_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
IPR027459 (Mel_rcpt_1.)
Pfam PF00001 (7tm_1)