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Target Report Card

Target Name and Classification

Target ID CHEMBL1943
Target Type SINGLE PROTEIN
Preferred Name HLA class II histocompatibility antigen DRB1-1
Synonyms DR-1 | DR1 | HLA class II histocompatibility antigen, DRB1-1 beta chain | HLA-DRB1 | MHC class II antigen DRB1*1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • surface antigen

Target Components

Component Description Relationship Accession
HLA class II histocompatibility antigen, DRB1-1 beta chain SINGLE PROTEIN P04229

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196126
Ensembl ENSG00000196126
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005764 (lysosome)
GO:0005765 (lysosomal membrane)
GO:0005768 (endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0010008 (endosome membrane)
GO:0012507 (ER to Golgi transport vesicle membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030658 (transport vesicle membrane)
GO:0030666 (endocytic vesicle membrane)
GO:0030669 (clathrin-coated endocytic vesicle membrane)
GO:0031902 (late endosome membrane)
GO:0032588 (trans-Golgi network membrane)
GO:0042613 (MHC class II protein complex)
GO:0070062 (extracellular exosome)
GO:0071556 (integral component of lumenal side of endoplasmic reticulum membrane)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0023026 (MHC class II protein complex binding)
GO:0042605 (peptide antigen binding)
GO Biological Process GO:0002376 (immune system process)
GO:0002381 (immunoglobulin production involved in immunoglobulin mediated immune response)
GO:0002437 (inflammatory response to antigenic stimulus)
GO:0002455 (humoral immune response mediated by circulating immunoglobulin)
GO:0002504 (antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)
GO:0006955 (immune response)
GO:0016032 (viral process)
GO:0016045 (detection of bacterium)
GO:0019882 (antigen processing and presentation)
GO:0019886 (antigen processing and presentation of exogenous peptide antigen via MHC class II)
GO:0031295 (T cell costimulation)
GO:0032673 (regulation of interleukin-4 production)
GO:0032689 (negative regulation of interferon-gamma production)
GO:0035774 (positive regulation of insulin secretion involved in cellular response to glucose stimulus)
GO:0042088 (T-helper 1 type immune response)
GO:0042130 (negative regulation of T cell proliferation)
GO:0046718 (viral entry into host cell)
GO:0050852 (T cell receptor signaling pathway)
GO:0051262 (protein tetramerization)
GO:0060333 (interferon-gamma-mediated signaling pathway)
GO:2001179 (regulation of interleukin-10 secretion)

Target Cross References - Protein

canSAR P04229
Human Protein Atlas ENSG00000196126
IntAct P04229
Open Targets ENSG00000196126
Reactome R-HSA-202424 (Downstream TCR signaling.)
R-HSA-202427 (Phosphorylation of CD3 and TCR zeta chains.)
R-HSA-202430 (Translocation of ZAP-70 to Immunological synapse.)
R-HSA-202433 (Generation of second messenger molecules.)
R-HSA-2132295 (MHC class II antigen presentation.)
R-HSA-389948 (PD-1 signaling.)
R-HSA-877300 (Interferon gamma signaling.)
UniProt A4F5N0 A8K098 O62869 P04229 P13758 Q06662 Q30116 Q30117 Q5Y7E9 Q7M2H4 Q95461 Q9BCL7 Q9GIK5 Q9MXZ0 Q9MXZ5 Q9TQ91

Target Cross References - Domain

InterPro IPR000353 (MHC_II_b_N.)
IPR003006 (Ig/MHC_CS.)
IPR003597 (Ig_C1-set.)
IPR007110 (Ig-like_dom.)
IPR011162 (MHC_I/II-like_Ag-recog.)
IPR013783 (Ig-like_fold.)
IPR014745 (MHC_II_a/b_N.)
Pfam PF00969 (MHC_II_beta)
PF07654 (C1-set)

Target Cross References - Structure

PDBe 1AQD 1DLH 1FYT 1HXY 1JWM 1JWS 1JWU 1KG0 1KLG 1KLU 1LO5 1PYW 1R5I 1SEB 1SJE 1SJH 1T5W 1T5X 2FSE 2G9H 2IAM 2IAN 2ICW 2IPK More...
CREDO 1AQD 1DLH 1FYT 1HXY 1JWM 1JWS 1JWU 1KG0 1KLG 1KLU 1LO5 1PYW 1R5I 1SEB 1SJE 1SJH 1T5W 1T5X 2FSE 2G9H 2IAM 2IAN 2ICW 2IPK More...
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