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Target Report Card

Target Name and Classification

Target ID CHEMBL1940
Preferred Name Voltage-gated L-type calcium channel alpha-1C subunit
Synonyms CACH2 | CACN2 | CACNA1C | CACNL1A1 | CCHL1A1 | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | Voltage-dependent L-type calcium channel subunit alpha-1C | Voltage-gated calcium channel subunit alpha Cav1.2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated calcium channel

Target Components

Component Description Relationship Accession
Voltage-dependent L-type calcium channel subunit alpha-1C SINGLE PROTEIN Q13936

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095229 Voltage-gated L-type calcium channel PROTEIN FAMILY
CHEMBL2363032 Voltage-gated calcium channel PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000151067
Ensembl ENSG00000151067
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005891 (voltage-gated calcium channel complex)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030018 (Z disc)
GO:1990454 (L-type voltage-gated calcium channel complex)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005245 (voltage-gated calcium channel activity)
GO:0005262 (calcium channel activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0008331 (high voltage-gated calcium channel activity)
GO:0046872 (metal ion binding)
GO:0051393 (alpha-actinin binding)
GO:0086007 (voltage-gated calcium channel activity involved in cardiac muscle cell action potential)
GO:0086056 (voltage-gated calcium channel activity involved in AV node cell action potential)
GO Biological Process GO:0002520 (immune system development)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007507 (heart development)
GO:0010881 (regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)
GO:0034765 (regulation of ion transmembrane transport)
GO:0035115 (embryonic forelimb morphogenesis)
GO:0035585 (calcium-mediated signaling using extracellular calcium source)
GO:0043010 (camera-type eye development)
GO:0050796 (regulation of insulin secretion)
GO:0055085 (transmembrane transport)
GO:0060402 (calcium ion transport into cytosol)
GO:0061337 (cardiac conduction)
GO:0061577 (calcium ion transmembrane transport via high voltage-gated calcium channel)
GO:0070588 (calcium ion transmembrane transport)
GO:0086002 (cardiac muscle cell action potential involved in contraction)
GO:0086012 (membrane depolarization during cardiac muscle cell action potential)
GO:0086045 (membrane depolarization during AV node cell action potential)
GO:0086064 (cell communication by electrical coupling involved in cardiac conduction)
GO:0086091 (regulation of heart rate by cardiac conduction)
GO:0098911 (regulation of ventricular cardiac muscle cell action potential)
GO:0098912 (membrane depolarization during atrial cardiac muscle cell action potential)
Wikipedia Cav1.2

Target Cross References - Protein

CGD Brugada syndrome 3; Timothy syndrome
Human Protein Atlas ENSG00000151067
IntAct Q13936
Guide to Pharmacology 529
Open Targets ENSG00000151067
PharmGKB PA83
Pharos Q13936 (Tclin)
Reactome R-HSA-400042 (Adrenaline,noradrenaline inhibits insulin secretion.)
R-HSA-419037 (NCAM1 interactions.)
R-HSA-422356 (Regulation of insulin secretion.)
R-HSA-5576892 (Phase 0 - rapid depolarisation.)
R-HSA-5576893 (Phase 2 - plateau phase.)
UniProt B2RUT3 E9PDJ0 Q13917 Q13918 Q13919 Q13920 Q13921 Q13922 Q13923 Q13924 Q13925 Q13926 Q13927 Q13928 Q13929 Q13930 Q13932 Q13933 Q13936 Q14743 Q14744 Q15877 Q4VMI7 Q4VMI8 Q4VMI9 Q6PKM7 Q8N6C0 Q99025 Q99241 Q99875

Target Cross References - Domain

InterPro IPR002077 (VDCCAlpha1.)
IPR005446 (VDCC_L_a1su.)
IPR005451 (VDCC_L_a1csu.)
IPR005821 (Ion_trans_dom.)
IPR014873 (VDCC_a1su_IQ.)
IPR027359 (Volt_channel_dom_sf.)
IPR031649 (GPHH_dom.)
IPR031688 (CAC1F_C.)
Pfam PF00520 (Ion_trans)
PF08763 (Ca_chan_IQ)
PF16885 (CAC1F_C)
PF16905 (GPHH)

Target Cross References - Structure

PDBe 1T0J 2BE6 2F3Y 2F3Z 3G43 3OXQ 5V2P 5V2Q
CREDO 1T0J 2BE6 2F3Y 2F3Z 3G43 3OXQ 5V2P 5V2Q