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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1921661
Target Type SINGLE PROTEIN
Preferred Name Arachidonate 5-lipoxygenase-activating protein
Synonyms Alox5ap | Arachidonate 5-lipoxygenase-activating protein | FLAP | Flap | MK-886-binding protein
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Arachidonate 5-lipoxygenase-activating protein SINGLE PROTEIN P20291

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031965 (nuclear membrane)
GO Molecular Function GO:0004051 (arachidonate 5-lipoxygenase activity)
GO:0004364 (glutathione transferase activity)
GO:0004464 (leukotriene-C4 synthase activity)
GO:0004602 (glutathione peroxidase activity)
GO:0008047 (enzyme activator activity)
GO:0019899 (enzyme binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO:0050544 (arachidonic acid binding)
GO Biological Process GO:0002540 (leukotriene production involved in inflammatory response)
GO:0002675 (positive regulation of acute inflammatory response)
GO:0006691 (leukotriene metabolic process)
GO:0019370 (leukotriene biosynthetic process)
GO:0019372 (lipoxygenase pathway)
GO:0043085 (positive regulation of catalytic activity)
GO:0055114 (oxidation-reduction process)
GO:0070207 (protein homotrimerization)

Target Cross References - Protein

IntAct P20291
Reactome R-RNO-2142688 (Synthesis of 5-eicosatetraenoic acids.)
R-RNO-2142691 (Synthesis of Leukotrienes (LT) and Eoxins (EX).)
R-RNO-2142700 (Synthesis of Lipoxins (LX).)
UniProt P20291 Q5RJL3

Target Cross References - Domain

InterPro IPR001129 (Membr-assoc_MAPEG.)
IPR001446 (5_LipOase_AP.)
IPR018295 (FLAP/GST2/LTC4S_CS.)
IPR023352 (MAPEG-like_dom_sf.)
Pfam PF01124 (MAPEG)
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