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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1914276
Target Type SINGLE PROTEIN
Preferred Name Inward rectifier potassium channel 2
Synonyms Cardiac inward rectifier potassium channel | IRK-1 | IRK1 | Inward rectifier K(+) channel Kir2.1 | Inward rectifier potassium channel 2 | KCNJ2 | Potassium channel, inwardly rectifying subfamily J member 2 | hIRK1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > potassium channels > inwardly rectifying potassium channel

Target Components

Component Description Relationship Accession
Inward rectifier potassium channel 2 SINGLE PROTEIN P63252

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201729 DRONEDARONE HYDROCHLORIDE Inward rectifier potassium channel 2 blocker 4 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000123700
Ensembl ENSG00000123700
GO Cellular Component GO:0005790 (smooth endoplasmic reticulum)
GO:0005791 (rough endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0008076 (voltage-gated potassium channel complex)
GO:0014704 (intercalated disc)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030315 (T-tubule)
GO:0030425 (dendrite)
GO:0031224 (intrinsic component of membrane)
GO:0043025 (neuronal cell body)
GO:0043197 (dendritic spine)
GO Molecular Function GO:0005242 (inward rectifier potassium channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005546 (phosphatidylinositol-4,5-bisphosphate binding)
GO:0015467 (G-protein activated inward rectifier potassium channel activity)
GO:0042802 (identical protein binding)
GO:0086008 (voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization)
GO Biological Process GO:0002027 (regulation of heart rate)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0010107 (potassium ion import)
GO:0014861 (regulation of skeletal muscle contraction via regulation of action potential)
GO:0015693 (magnesium ion transport)
GO:0030007 (cellular potassium ion homeostasis)
GO:0034765 (regulation of ion transmembrane transport)
GO:0051289 (protein homotetramerization)
GO:0055119 (relaxation of cardiac muscle)
GO:0060075 (regulation of resting membrane potential)
GO:0060306 (regulation of membrane repolarization)
GO:0061337 (cardiac conduction)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071805 (potassium ion transmembrane transport)
GO:0086001 (cardiac muscle cell action potential)
GO:0086002 (cardiac muscle cell action potential involved in contraction)
GO:0086004 (regulation of cardiac muscle cell contraction)
GO:0086011 (membrane repolarization during action potential)
GO:0086012 (membrane depolarization during cardiac muscle cell action potential)
GO:0086013 (membrane repolarization during cardiac muscle cell action potential)
GO:0086091 (regulation of heart rate by cardiac conduction)
GO:0090076 (relaxation of skeletal muscle)
GO:1901381 (positive regulation of potassium ion transmembrane transport)

Target Cross References - Protein

CGD Atrial fibrillation, familial 9; Short QT syndrome 3; Andersen syndrome; Long QT syndrome 7
Human Protein Atlas ENSG00000123700
IntAct P63252
Open Targets ENSG00000123700
PharmGKB PA214
Pharos P63252 (Tbio)
Reactome R-HSA-1296041 (Activation of G protein gated Potassium channels.)
R-HSA-1296053 (Classical Kir channels.)
R-HSA-5576886 (Phase 4 - resting membrane potential.)
R-HSA-997272 (Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.)
UniProt O15110 P48049 P63252

Target Cross References - Domain

InterPro IPR003271 (K_chnl_inward-rec_Kir2.1.)
IPR013518 (K_chnl_inward-rec_Kir_cyto.)
IPR013673 (K_chnl_inward-rec_Kir_N.)
IPR014756 (Ig_E-set.)
IPR016449 (K_chnl_inward-rec_Kir.)
Pfam PF01007 (IRK)
PF08466 (IRK_N)
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