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Target Report Card

Target Name and Classification

Target ID CHEMBL1913
Target Type SINGLE PROTEIN
Preferred Name Platelet-derived growth factor receptor beta
Synonyms Beta platelet-derived growth factor receptor | Beta-type platelet-derived growth factor receptor | CD140 antigen-like family member B | CD_antigen=CD140b | PDGF-R-beta | PDGFR | PDGFR-1 | PDGFR-beta | PDGFR1 | PDGFRB | Platelet-derived growth factor receptor 1 | Platelet-derived growth factor receptor beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase pdgfr family

Target Components

Component Description Relationship Accession
Platelet-derived growth factor receptor beta SINGLE PROTEIN P09619

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095189 Platelet-derived growth factor receptor PROTEIN COMPLEX
CHEMBL2111440 VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta) SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1421 DASATINIB Platelet-derived growth factor receptor beta inhibitor 4 DailyMed
CHEMBL1642 IMATINIB MESYLATE Platelet-derived growth factor receptor beta inhibitor 4 DailyMed
CHEMBL1200485 SORAFENIB TOSYLATE Platelet-derived growth factor receptor beta inhibitor 4 FDA
CHEMBL124660 TANDUTINIB Platelet-derived growth factor receptor beta inhibitor 2 Other PubMed PubMed
CHEMBL403989 TG100-801 Platelet-derived growth factor receptor beta inhibitor 2 PubMed PubMed PubMed
CHEMBL2079588 TELATINIB Platelet-derived growth factor receptor beta inhibitor 2 PubMed PubMed
CHEMBL2109544 CDP-860 Platelet-derived growth factor receptor beta inhibitor 2 PubMed
CHEMBL3545021 ANLOTINIB Platelet-derived growth factor receptor beta inhibitor 2 ClinicalTrials Other
CHEMBL3545155 JI-101 Platelet-derived growth factor receptor beta inhibitor 2 DOI PubMed
CHEMBL3545427 CM-082 Platelet-derived growth factor receptor beta inhibitor 2 Other
CHEMBL1980391 RG-1530 Platelet-derived growth factor receptor beta inhibitor 1 PubMed PubMed
CHEMBL3545088 PUQUITINIB Platelet-derived growth factor receptor beta inhibitor 1 DOI PubMed PubMed
CHEMBL3545196 PD-0166285 Platelet-derived growth factor receptor beta inhibitor 1 PubMed
CHEMBL3545332 CEP-2563 Platelet-derived growth factor receptor beta inhibitor 1 PubMed PubMed PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000113721
Ensembl ENSG00000113721
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0031226 (intrinsic component of plasma membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0043202 (lysosomal lumen)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0004992 (platelet activating factor receptor activity)
GO:0005017 (platelet-derived growth factor-activated receptor activity)
GO:0005019 (platelet-derived growth factor beta-receptor activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005102 (receptor binding)
GO:0005161 (platelet-derived growth factor receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0038085 (vascular endothelial growth factor binding)
GO:0043548 (phosphatidylinositol 3-kinase binding)
GO:0046934 (phosphatidylinositol-4,5-bisphosphate 3-kinase activity)
GO:0048407 (platelet-derived growth factor binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0006024 (glycosaminoglycan biosynthetic process)
GO:0006468 (protein phosphorylation)
GO:0006935 (chemotaxis)
GO:0007165 (signal transduction)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007275 (multicellular organism development)
GO:0007568 (aging)
GO:0008284 (positive regulation of cell proliferation)
GO:0008584 (male gonad development)
GO:0009636 (response to toxic substance)
GO:0010863 (positive regulation of phospholipase C activity)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0014070 (response to organic cyclic compound)
GO:0014911 (positive regulation of smooth muscle cell migration)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030335 (positive regulation of cell migration)
GO:0032355 (response to estradiol)
GO:0032516 (positive regulation of phosphoprotein phosphatase activity)
GO:0032526 (response to retinoic acid)
GO:0032956 (regulation of actin cytoskeleton organization)
GO:0032967 (positive regulation of collagen biosynthetic process)
GO:0033993 (response to lipid)
GO:0034405 (response to fluid shear stress)
GO:0035025 (positive regulation of Rho protein signal transduction)
GO:0035441 (cell migration involved in vasculogenesis)
GO:0035556 (intracellular signal transduction)
GO:0035789 (metanephric mesenchymal cell migration)
GO:0035791 (platelet-derived growth factor receptor-beta signaling pathway)
GO:0035793 (positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway)
GO:0035909 (aorta morphogenesis)
GO:0036120 (cellular response to platelet-derived growth factor stimulus)
GO:0038091 (positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)
GO:0042060 (wound healing)
GO:0042542 (response to hydrogen peroxide)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043552 (positive regulation of phosphatidylinositol 3-kinase activity)
GO:0043627 (response to estrogen)
GO:0045840 (positive regulation of mitotic nuclear division)
GO:0046488 (phosphatidylinositol metabolic process)
GO:0046777 (protein autophosphorylation)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048008 (platelet-derived growth factor receptor signaling pathway)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0048839 (inner ear development)
GO:0050921 (positive regulation of chemotaxis)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0055003 (cardiac myofibril assembly)
GO:0055093 (response to hyperoxia)
GO:0060326 (cell chemotaxis)
GO:0060437 (lung growth)
GO:0060981 (cell migration involved in coronary angiogenesis)
GO:0061298 (retina vasculature development in camera-type eye)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071670 (smooth muscle cell chemotaxis)
GO:0072075 (metanephric mesenchyme development)
GO:0072262 (metanephric glomerular mesangial cell proliferation involved in metanephros development)
GO:0072275 (metanephric glomerulus morphogenesis)
GO:0072277 (metanephric glomerular capillary formation)
GO:0072278 (metanephric comma-shaped body morphogenesis)
GO:0072284 (metanephric S-shaped body morphogenesis)
GO:0090280 (positive regulation of calcium ion import)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
GO:2000491 (positive regulation of hepatic stellate cell activation)
GO:2000573 (positive regulation of DNA biosynthetic process)
GO:2000587 (negative regulation of platelet-derived growth factor receptor-beta signaling pathway)
Wikipedia PDGFRB

Target Cross References - Protein

canSAR P09619
CGD Basal ganglia calcification, idiopathic, 4
Human Protein Atlas ENSG00000113721
IntAct P09619
Guide to Pharmacology 1804
Open Targets ENSG00000113721
PharmGKB PA33148
Pharos P09619 (Tclin)
Reactome R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-186763 (Downstream signal transduction.)
R-HSA-186797 (Signaling by PDGF.)
R-HSA-2219530 (Constitutive Signaling by Aberrant PI3K in Cancer.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
UniProt B5A957 P09619 Q8N5L4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001824 (Tyr_kinase_rcpt_3_CS.)
IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR013098 (Ig_I-set.)
IPR013151 (Immunoglobulin.)
IPR013783 (Ig-like_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR027288 (PGFRB.)
IPR036179 (Ig-like_dom_sf.)
Pfam PF00047 (ig)
PF07679 (I-set)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1GQ5 1H9O 1SHA 3MJG
CREDO 1GQ5 1H9O 1SHA 3MJG
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