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Target Report Card

Target Name and Classification

Target ID CHEMBL1910
Preferred Name Adenosine deaminase
Synonyms ADA | ADA1 | Adenosine aminohydrolase | Adenosine deaminase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Adenosine deaminase SINGLE PROTEIN P00813

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1580 PENTOSTATIN Adenosine deaminase inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196839
Ensembl ENSG00000196839
GO Cellular Component GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0030054 (cell junction)
GO:0031410 (cytoplasmic vesicle)
GO:0032839 (dendrite cytoplasm)
GO:0043025 (neuronal cell body)
GO:0060205 (cytoplasmic membrane-bounded vesicle lumen)
GO Molecular Function GO:0001883 (purine nucleoside binding)
GO:0004000 (adenosine deaminase activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0019239 (deaminase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0001701 (in utero embryonic development)
GO:0001821 (histamine secretion)
GO:0001829 (trophectodermal cell differentiation)
GO:0001889 (liver development)
GO:0001890 (placenta development)
GO:0002314 (germinal center B cell differentiation)
GO:0002636 (positive regulation of germinal center formation)
GO:0002686 (negative regulation of leukocyte migration)
GO:0002906 (negative regulation of mature B cell apoptotic process)
GO:0006154 (adenosine catabolic process)
GO:0006157 (deoxyadenosine catabolic process)
GO:0007155 (cell adhesion)
GO:0007568 (aging)
GO:0009117 (nucleotide metabolic process)
GO:0009168 (purine ribonucleoside monophosphate biosynthetic process)
GO:0010460 (positive regulation of heart rate)
GO:0030324 (lung development)
GO:0030890 (positive regulation of B cell proliferation)
GO:0032261 (purine nucleotide salvage)
GO:0033089 (positive regulation of T cell differentiation in thymus)
GO:0033197 (response to vitamin E)
GO:0033632 (regulation of cell-cell adhesion mediated by integrin)
GO:0042110 (T cell activation)
GO:0042323 (negative regulation of circadian sleep/wake cycle, non-REM sleep)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0043066 (negative regulation of apoptotic process)
GO:0043101 (purine-containing compound salvage)
GO:0043103 (hypoxanthine salvage)
GO:0043278 (response to morphine)
GO:0045187 (regulation of circadian sleep/wake cycle, sleep)
GO:0045580 (regulation of T cell differentiation)
GO:0045582 (positive regulation of T cell differentiation)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0046061 (dATP catabolic process)
GO:0046085 (adenosine metabolic process)
GO:0046101 (hypoxanthine biosynthetic process)
GO:0046103 (inosine biosynthetic process)
GO:0046111 (xanthine biosynthetic process)
GO:0046638 (positive regulation of alpha-beta T cell differentiation)
GO:0048286 (lung alveolus development)
GO:0048541 (Peyer's patch development)
GO:0048566 (embryonic digestive tract development)
GO:0050728 (negative regulation of inflammatory response)
GO:0050850 (positive regulation of calcium-mediated signaling)
GO:0050862 (positive regulation of T cell receptor signaling pathway)
GO:0050870 (positive regulation of T cell activation)
GO:0060169 (negative regulation of adenosine receptor signaling pathway)
GO:0060407 (negative regulation of penile erection)
GO:0070244 (negative regulation of thymocyte apoptotic process)
GO:0070256 (negative regulation of mucus secretion)
Wikipedia Adenosine_deaminase

Target Cross References - Protein

canSAR P00813
CGD Severe combined immunodeficiency due to adenosine deaminase deficiency
Human Protein Atlas ENSG00000196839
IntAct P00813
Guide to Pharmacology 1230
Open Targets ENSG00000196839
PharmGKB PA24503
Reactome R-HSA-74217 (Purine salvage.)
UniProt P00813 Q53F92 Q6LA59

Target Cross References - Domain

InterPro IPR001365 (A/AMP_deaminase_dom.)
IPR006330 (Ado/ade_deaminase.)
IPR006650 (A/AMP_deam_AS.)
IPR028893 (A_deaminase.)
IPR032466 (Metal_Hydrolase.)
Pfam PF00962 (A_deaminase)

Target Cross References - Structure