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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1908385
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase pknB
Synonyms Serine/threonine-protein kinase PknB | pknB
Organism Mycobacterium tuberculosis
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase PknB SINGLE PROTEIN P9WI81

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005618 (cell wall)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030145 (manganese ion binding)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0008360 (regulation of cell shape)
GO:0009405 (pathogenesis)
GO:0016310 (phosphorylation)
GO:0032091 (negative regulation of protein binding)
GO:0040007 (growth)
GO:0043085 (positive regulation of catalytic activity)
GO:0043086 (negative regulation of catalytic activity)
GO:0043388 (positive regulation of DNA binding)
GO:0045717 (negative regulation of fatty acid biosynthetic process)
GO:0046777 (protein autophosphorylation)
GO:0051338 (regulation of transferase activity)
GO:0052572 (response to host immune response)

Target Cross References - Protein

IntAct P9WI81
UniProt L0T5F6 P0A5S4 P71584 P9WI81

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR005543 (PASTA_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
PF03793 (PASTA)

Target Cross References - Structure

PDBe 1MRU 1O6Y 2FUM 3F61 3F69 5E0Y 5E0Z 5E10 5E12
CREDO 1MRU 1O6Y 2FUM 3F61 3F69 5E0Y 5E0Z 5E10 5E12
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