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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1907603
Target Type PROTEIN COMPLEX
Preferred Name Glutamate NMDA receptor; GRIN1/GRIN2B
Synonyms GRIN1 | GRIN2B | GluN1 | GluN2B | Glutamate [NMDA] receptor subunit epsilon-2 | Glutamate [NMDA] receptor subunit zeta-1 | Glutamate receptor ionotropic, NMDA 1 | Glutamate receptor ionotropic, NMDA 2B | N-methyl D-aspartate receptor subtype 2B | N-methyl-D-aspartate receptor subunit 3 | N-methyl-D-aspartate receptor subunit NR1 | NMD-R1 | NMDAR1 | NMDAR2B | NMDAR2B | NR2B | NR3 | hNR3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > nmda receptor

Target Components

Component Description Relationship Accession
Glutamate receptor ionotropic, NMDA 2B PROTEIN SUBUNIT Q13224
Glutamate receptor ionotropic, NMDA 1 PROTEIN SUBUNIT Q05586

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2015 Glutamate (NMDA) receptor subunit zeta 1 SINGLE PROTEIN
CHEMBL2094124 Glutamate [NMDA] receptor PROTEIN COMPLEX GROUP
CHEMBL3038505 Ionotropic glutamate receptor NMDA 1/2D PROTEIN COMPLEX
CHEMBL3038504 Ionotropic glutamate receptor NMDA 1/2C PROTEIN COMPLEX
CHEMBL1907604 Glutamate NMDA receptor; GRIN1/GRIN2A PROTEIN COMPLEX
CHEMBL1904 Glutamate [NMDA] receptor subunit epsilon 2 SINGLE PROTEIN

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL17350 TRAXOPRODIL Glutamate NMDA receptor; GRIN1/GRIN2B antagonist 2 DOI PubMed PubMed
CHEMBL182066 RADIPRODIL Glutamate NMDA receptor; GRIN1/GRIN2B antagonist 2
CHEMBL2068839 RISLENEMDAZ Glutamate NMDA receptor; GRIN1/GRIN2B antagonist 2 Other PubMed PubMed
CHEMBL3545349 EVT-101 Glutamate NMDA receptor; GRIN1/GRIN2B antagonist 2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

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