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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1907594
Target Type PROTEIN COMPLEX
Preferred Name Neuronal acetylcholine receptor; alpha3/beta4
Synonyms CHRNA3 | CHRNB4 | NACHRA3 | Neuronal acetylcholine receptor subunit alpha-3 | Neuronal acetylcholine receptor subunit beta-4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > nicotinic acetylcholine receptor > nicotinic acetylcholine receptor alpha subunit
  • ion channel > ligand-gated ion channel > nicotinic acetylcholine receptor > nicotinic acetylcholine receptor beta subunit

Target Components

Component Description Relationship Accession
Neuronal acetylcholine receptor subunit beta-4 PROTEIN SUBUNIT P30926
Neuronal acetylcholine receptor subunit alpha-3 PROTEIN SUBUNIT P32297

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3137273 Nicotinic acetylcholine receptor alpha3/beta4/alpha5 PROTEIN COMPLEX
CHEMBL3137272 Nicotinic acetylcholine receptor alpha3/beta2/alpha5 PROTEIN COMPLEX
CHEMBL2221346 Neuronal acetylcholine receptors; alpha-3/beta-4, alpha-5, beta-2 PROTEIN COMPLEX GROUP
CHEMBL3137285 Nicotinic acetylcholine receptor alpha6/alpha3/beta4 PROTEIN COMPLEX
CHEMBL3038459 Nicotinic acetylcholine receptor alpha2/beta4 PROTEIN COMPLEX
CHEMBL3068 Neuronal acetylcholine receptor subunit alpha-3 SINGLE PROTEIN
CHEMBL2111384 Nicotinic acetylcholine receptor alpha3/betaX PROTEIN COMPLEX GROUP
CHEMBL2109230 Neuronal acetylcholine receptor; alpha2/beta4 PROTEIN COMPLEX
CHEMBL1907591 Neuronal acetylcholine receptor; alpha4/beta4 PROTEIN COMPLEX
CHEMBL2109234 Neuronal acetylcholine receptor; alpha3/beta2 PROTEIN COMPLEX
CHEMBL2109233 Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1245 TRIMETHAPHAN CAMSYLATE Neuronal acetylcholine receptor; alpha3/beta4 antagonist 4 ISBN PubMed
CHEMBL1237082 MECAMYLAMINE HYDROCHLORIDE Neuronal acetylcholine receptor; alpha3/beta4 negative allosteric modulator 4 DailyMed PubMed
CHEMBL1318287 PENTOLINIUM TARTRATE Neuronal acetylcholine receptor; alpha3/beta4 antagonist 4 PubMed
CHEMBL2103815 LARAZOTIDE ACETATE Neuronal acetylcholine receptor; alpha3/beta4 partial agonist 2 PubMed
CHEMBL3545353 TC-6499 Neuronal acetylcholine receptor; alpha3/beta4 agonist 2 Other PubMed
CHEMBL3707249 ASM-024 Neuronal acetylcholine receptor; alpha3/beta4 antagonist 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

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