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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1907589
Target Type PROTEIN COMPLEX
Preferred Name Neuronal acetylcholine receptor; alpha4/beta2
Synonyms CHRNA4 | CHRNB2 | NACRA4 | Neuronal acetylcholine receptor subunit alpha-4 | Neuronal acetylcholine receptor subunit beta-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > nicotinic acetylcholine receptor > nicotinic acetylcholine receptor alpha subunit
  • ion channel > ligand-gated ion channel > nicotinic acetylcholine receptor > nicotinic acetylcholine receptor beta subunit

Target Components

Component Description Relationship Accession
Neuronal acetylcholine receptor subunit beta-2 PROTEIN SUBUNIT P17787
Neuronal acetylcholine receptor subunit alpha-4 PROTEIN SUBUNIT P43681

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2109236 Neuronal acetylcholine receptor; alpha2/beta2 PROTEIN COMPLEX
CHEMBL3137272 Nicotinic acetylcholine receptor alpha3/beta2/alpha5 PROTEIN COMPLEX
CHEMBL2109237 Neuronal acetylcholine receptor; alpha6/beta2 PROTEIN COMPLEX
CHEMBL2221346 Neuronal acetylcholine receptors; alpha-3/beta-4, alpha-5, beta-2 PROTEIN COMPLEX GROUP
CHEMBL3038458 Nicotinic acetylcholine receptor alpha2/beta2 PROTEIN COMPLEX
CHEMBL1882 Neuronal acetylcholine receptor protein alpha-4 subunit SINGLE PROTEIN
CHEMBL3038461 Nicotinic acetylcholine receptor alpha4/beta2/alpha5 PROTEIN COMPLEX
CHEMBL3885595 Integrin alpha-5/Neuronal acetylcholine receptor subunit alpha-3/Neuronal acetylcholine receptor subunit beta-2/Neuronal acetylcholine receptor subunit beta-4 PROTEIN COMPLEX
CHEMBL1883 Neuronal acetylcholine receptor protein beta-2 subunit SINGLE PROTEIN
CHEMBL2111384 Nicotinic acetylcholine receptor alpha3/betaX PROTEIN COMPLEX GROUP
CHEMBL1907591 Neuronal acetylcholine receptor; alpha4/beta4 PROTEIN COMPLEX
CHEMBL2109234 Neuronal acetylcholine receptor; alpha3/beta2 PROTEIN COMPLEX
CHEMBL2109233 Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3 NICOTINE Neuronal acetylcholine receptor; alpha4/beta2 agonist 4 PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed
CHEMBL1201536 NICOTINE POLACRILEX Neuronal acetylcholine receptor; alpha4/beta2 agonist 4 PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed
CHEMBL2062259 VARENICLINE TARTRATE Neuronal acetylcholine receptor; alpha4/beta2 agonist 4 DailyMed
CHEMBL2103881 DEXMECAMYLAMINE Neuronal acetylcholine receptor; alpha4/beta2 antagonist 3 PubMed PubMed
CHEMBL188462 ISPRONICLINE Neuronal acetylcholine receptor; alpha4/beta2 partial agonist 2 Other PubMed
CHEMBL238465 SOFINICLINE Neuronal acetylcholine receptor; alpha4/beta2 agonist 2 PubMed PubMed
CHEMBL2104964 TEBANICLINE TOSYLATE Neuronal acetylcholine receptor; alpha4/beta2 agonist 2 PubMed
CHEMBL2179529 AZD1446 Neuronal acetylcholine receptor; alpha4/beta2 agonist 2 PubMed
CHEMBL3545353 TC-6499 Neuronal acetylcholine receptor; alpha4/beta2 agonist 2 Other PubMed
CHEMBL3707250 CP-601927 Neuronal acetylcholine receptor; alpha4/beta2 partial agonist 2 Other
CHEMBL504652 TC-2216 Neuronal acetylcholine receptor; alpha4/beta2 antagonist 1 PubMed PubMed
CHEMBL111659 ALTINICLINE Neuronal acetylcholine receptor; alpha4/beta2 agonist 0 PubMed PubMed
CHEMBL3707354 ABT-560 Neuronal acetylcholine receptor; alpha4/beta2 modulator 0 Other
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Protein

MICAD NBK23083 (Nicotinic acetylcholine receptor (nAChR) alpha4/beta2)
NBK23401 (Nicotinic acetylcholine receptor (nAChR) alpha4/beta2)
NBK23587 (Nicotinic acetylcholine receptor (nAChR) alpha4/beta2)
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