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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1907
Target Type SINGLE PROTEIN
Preferred Name Aminopeptidase N
Synonyms ANPEP | AP-M | AP-N | APN | Alanyl aminopeptidase | Aminopeptidase M | Aminopeptidase N | CD13 | CD_antigen=CD13 | Microsomal aminopeptidase | Myeloid plasma membrane glycoprotein CD13 | PEPN | gp150 | hAPN
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m1 family

Target Components

Component Description Relationship Accession
Aminopeptidase N SINGLE PROTEIN P15144

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831223 Aminopeptidase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166825
Ensembl ENSG00000166825
GO Cellular Component GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005765 (lysosomal membrane)
GO:0005793 (endoplasmic reticulum-Golgi intermediate compartment)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0012506 (vesicle membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031983 (vesicle lumen)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0004177 (aminopeptidase activity)
GO:0004872 (receptor activity)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0042277 (peptide binding)
GO:0046872 (metal ion binding)
GO:0070006 (metalloaminopeptidase activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0006508 (proteolysis)
GO:0006725 (cellular aromatic compound metabolic process)
GO:0007275 (multicellular organism development)
GO:0016032 (viral process)
GO:0030154 (cell differentiation)
GO:0035814 (negative regulation of renal sodium excretion)
GO:0043171 (peptide catabolic process)
GO:0046718 (viral entry into host cell)
Wikipedia Alanine_aminopeptidase

Target Cross References - Protein

canSAR P15144
Human Protein Atlas ENSG00000166825
IntAct P15144
Guide to Pharmacology 1560
Open Targets ENSG00000166825
PharmGKB PA24815
Reactome R-HSA-2022377 (Metabolism of Angiotensinogen to Angiotensins.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt P15144 Q16728 Q6GT90 Q8IUK3 Q8IVH3 Q9UCE0

Target Cross References - Domain

InterPro IPR001930 (Peptidase_M1.)
IPR014782 (Peptidase_M1_N.)
IPR024571 (ERAP1-like_C_dom.)
IPR034016 (M1_APN-typ.)
Pfam PF01433 (Peptidase_M1)
PF11838 (ERAP1_C)

Target Cross References - Structure

PDBe 4FYQ 4FYR 4FYS 4FYT
CREDO 4FYQ 4FYR 4FYS 4FYT
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